Motile cells extend a leading edge by assembling a branched network of actin filaments that
produces physical force as the polymers grow beneath the plasma membrane. A core set of …

Recently, a consensus has emerged that cofilin severing activity can generate free actin
filament ends that are accessible for F-actin polymerization and depolymerization without …

Brain circuits undergo substantial structural changes during development, driven by the
formation, stabilization, and elimination of synapses. Synaptic connections continue to …

Malignant cancer cells utilize their intrinsic migratory ability to invade adjacent tissues and
the vasculature, and ultimately to metastasize. Cell migration is the sum of multi-step …

The actin cytoskeleton is a complex structure that performs a wide range of cellular
functions. In 2001, significant advances were made to our understanding of the structure and …

Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …

The actin depolymerizing factor (ADF)/cofilin family comprises small actin-binding proteins
with crucial roles in development, tissue homeostasis and disease. They are best known for …

Activity-induced modification of neuronal connections is essential for the development of the
nervous system and may also underlie learning and memory functions of mature brain …

DUSPs (dual-specificity phosphatases) are a heterogeneous group of protein phosphatases
that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine …

To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms
adhesions, and finally retracts its tail. The actin cytoskeleton plays a major role in this …