Macrophages, a type of myeloid immune cell, play essential roles in fighting against
pathogenic invasion and activating T cell-mediated adaptive immune responses. As a major …

The chemotactic cytokine fractalkine (FKN, chemokine CX3CL1) has unique properties
resulting from the combination of chemoattractants and adhesion molecules. The soluble …

Tumor microenvironment (TME) has been reported to exhibit a crucial effect in lung cancer.
Therefore, this study was aimed to investigate the genes associated with TME and develop a …

Purpose: The addition of immune checkpoint blockade (ICB) to platinum/etoposide
chemotherapy changed the standard of care for small cell lung cancer (SCLC) treatment …

Background TAMs (tumor-associated macrophages) infiltration promotes the progression of
esophageal cancer (EC). However, the underlying mechanisms remain unclear. Methods …

Clear cell renal cell carcinoma (ccRCC) is characterized by dysregulated hypoxia signaling
and a tumor microenvironment (TME) highly enriched in myeloid and lymphoid cells. Loss of …

Background Predictive biomarkers in use for immunotherapy in advanced non-small cell
lung cancer are of limited sensitivity and specificity. We analysed the potential of activating …

The tumor microenvironment (TME) plays an important role in the pathogenesis of many
cancers. We aimed to screen the TME-related hub genes of colorectal adenoma (CRAD) …

Macrophages are immune cells with high plasticity that are widely distributed in all tissues
and organs of the body. Under the influence of the immune microenvironment of breast …

Chemokines, a subfamily of the cell cytokines, are low molecular weight proteins known to
induce chemotaxis in leukocytes in response to inflammatory and pathogenic signals. A …