The evolutionarily conserved p53 protein and its cellular pathways mediate tumour
suppression through an informed, regulated and integrated set of responses to …

In this review we attempt to reconstruct the evolutionary history of hominin life history from
extant and fossil evidence. We utilize demographic life history theory and distinguish life …

Women born at different periods within the 20th century in England and Wales have
followed varying fertility pathways with large changes in, for example, proportions having no …

Exceptional longevity represents an extreme phenotype. Current centenarians are survivors
of a cohort who display delayed onset of age-related diseases and/or resistance to …

Postponement has been a major keyword in the description and the study of demographic
trends observed in developed countries during the last decades. With few exceptions, during …

Mortality in women who have completed their childbearing may increase with the number of
births experienced because of maternal depletion or a trade-off between reproduction and …

There is growing recognition that reproductive patterns may have long-term health
implications, although most evidence is restricted to women. The authors used register data …

In human females allocation of resources to support reproduction may cause their
insufficient supply to other metabolic functions, resulting in compromised physiology …

Frontier populations provide exceptional opportunities to test the hypothesis of a trade‐off
between fertility and longevity. In such populations, mechanisms favoring reproduction …

Research into the genetic component of human longevity can provide important insights in
mechanisms that may protect against age-related diseases and multi-morbidity. Thus far …