Over the past decade, RNA sequencing (RNA-seq) has become an indispensable tool for
transcriptome-wide analysis of differential gene expression and differential splicing of …

Abstract Purpose of Review Ankylosing spondylitis (AS) is strongly associated with the HLA-
B27 gene. The canonical function of HLA-B27 is to present antigenic peptides to CD8 …

Background The T-cell receptor (TCR), located on the surface of T cells, is responsible for
the recognition of the antigen-major histocompatibility complex, leading to the initiation of an …

Interest in single-cell whole-transcriptome analysis is growing rapidly, especially for profiling
rare or heterogeneous populations of cells. We compared commercially available single-cell …

The decrease of TCR diversity with aging has never been studied by direct methods. In this
study, we combined high-throughput Illumina sequencing with unique cDNA molecular …

We have cloned six fluorescent proteins homologous to the green fluorescent protein (GFP)
from Aequorea victoria. Two of these have spectral characteristics dramatically different from …

We developed a massive-scale RNA sequencing protocol, short quantitative random RNA
libraries or SQRL, to survey the complexity, dynamics and sequence content of …

Background: The injection of double-stranded RNA (dsRNA) has been shown to induce a
potent sequence-specific inhibition of gene function in diverse invertebrate and vertebrate …

Elevated temperatures resulting from climate change pose a clear threat to reef‐building
corals; however, the traits that might influence corals' survival and dispersal during climate …

High-throughput sequencing dramatically changed our view of transcriptome architectures
and allowed for ground-breaking discoveries in RNA biology. Recently, sequencing of full …