Since its recent discovery, the meningeal lymphatic system has reshaped our understanding
of central nervous system (CNS) fluid exchange, waste clearance, immune cell trafficking …

Traumatic injuries of the central nervous system (CNS) affect millions of people worldwide,
and they can lead to severely damaging consequences such as permanent disability and …

Traumatic injuries to the central nervous system (CNS) afflict millions of individuals
worldwide, yet an effective treatment remains elusive. Following such injuries, the site is …

The chemokine CXC-ligand 13 (CXCL13) is a major B cell chemoattractant to B cell follicles
in secondary lymphoid organs (SLO) that proposedly recruits B cells to the cerebrospinal …

Most antibodies produced in the body are of the IgA class. The dominant cell population
producing them are plasma cells within the lamina propria of the gastrointestinal tract, but …

Background Ischemic stroke is a leading cause of mortality worldwide, largely due to the
inflammatory response to brain ischemia during post-stroke reperfusion. Despite ongoing …

The lymphatic vasculature plays a crucial role in fluid clearance and immune responses in
peripheral organs by connecting them to distal lymph nodes. Recently, attention has been …

The immune system has emerged as a key regulator of central nervous system (CNS)
function in health and in disease. Importantly, improved understanding of immune …

The meninges are important for brain development and pathology. Using single-cell RNA
sequencing, we have generated the first comprehensive transcriptional atlas of neonatal …

Simple Summary The tumor immune microenvironment is an important area of tumor
research. Tertiary lymphoid structures, as a specific component of this, have recently begun …