Brainstem circuits for locomotion

R Leiras, JM Cregg, O Kiehn - Annual review of neuroscience, 2022 - annualreviews.org
Locomotion is a universal motor behavior that is expressed as the output of many integrated
brain functions. Locomotion is organized at several levels of the nervous system, with …

Neural modulation with photothermally active nanomaterials

Y Wang, R Garg, D Cohen-Karni… - Nature Reviews …, 2023 - nature.com
Modulating neural electrophysiology with high precision is essential for understanding
neural communication and for the diagnosis and treatment of neural disorders. Photothermal …

Pedunculopontine Chx10+ neurons control global motor arrest in mice

H Goñi-Erro, R Selvan, V Caggiano, R Leiras… - Nature …, 2023 - nature.com
Arrest of ongoing movements is an integral part of executing motor programs. Behavioral
arrest may happen upon termination of a variety of goal-directed movements or as a global …

Deconstructing the modular organization and real-time dynamics of mammalian spinal locomotor networks

LJ Hsu, M Bertho, O Kiehn - Nature communications, 2023 - nature.com
Locomotion empowers animals to move. Locomotor-initiating signals from the brain are
funneled through descending neurons in the brainstem that act directly on spinal locomotor …

Pattern decorrelation in the mouse medial prefrontal cortex enables social preference and requires MeCP2

P Xu, Y Yue, J Su, X Sun, H Du, Z Liu, R Simha… - Nature …, 2022 - nature.com
Sociability is crucial for survival, whereas social avoidance is a feature of disorders such as
Rett syndrome, which is caused by loss-of-function mutations in MECP2. To understand how …

[HTML][HTML] Chronic cadmium exposure induces Parkinson-like syndrome by eliciting sphingolipid disturbance and neuroinflammation in the midbrain of C57BL/6J mice

Y Xu, H Hong, X Lin, T Tong, J Zhang, H He… - Environmental …, 2023 - Elsevier
Cadmium (Cd) is known as a widespread environmental neurotoxic pollutant. Cd exposure
is recently recognized as an etiological factor of Parkinson's disease (PD) in humans …

Ultrathin niobium carbide MXenzyme for remedying hypertension by antioxidative and neuroprotective actions

H Yang, L **a, X Ye, J Xu, T Liu, L Wang… - Angewandte …, 2023 - Wiley Online Library
Hypertension, as a leading risk factor for cardiovascular diseases, is associated with
oxidative stress and impairment of endogenous antioxidant mechanisms, but there is still a …

Neuronal and synaptic adaptations underlying the benefits of deep brain stimulation for Parkinson's disease

W Xu, J Wang, XN Li, J Liang, L Song, Y Wu… - Translational …, 2023 - Springer
Deep brain stimulation (DBS) is a well-established and effective treatment for patients with
advanced Parkinson's disease (PD), yet its underlying mechanisms remain enigmatic …

Locomotor pattern generation and descending control: a historical perspective

R Dubuc, JM Cabelguen… - Journal of …, 2023 - journals.physiology.org
The ability to generate and control locomotor movements depends on complex interactions
between many areas of the nervous system, the musculoskeletal system, and the …

The mesencephalic locomotor region: beyond locomotor control

BR Noga, PJ Whelan - Frontiers in neural circuits, 2022 - frontiersin.org
The mesencephalic locomotor region (MLR) was discovered several decades ago in the cat.
It was functionally defined based on the ability of low threshold electrical stimuli within a …