Cell migration is dependent on the dynamic formation and disassembly of actin filament–
based structures, including lamellipodia, filopodia, invadopodia, and membrane blebs, as …

Recently, a consensus has emerged that cofilin severing activity can generate free actin
filament ends that are accessible for F-actin polymerization and depolymerization without …

Rho GTPases play an essential role in regulating cell spreading, adhesion, and migration
downstream of integrin engagement with the extracellular matrix. In this review, we focus on …

Malignant carcinomas are often characterized by metastasis, the movement of carcinoma
cells from a primary site to colonize distant organs. For metastasis to occur, carcinoma cells …

The Rho subfamily members of Rho GTPases, RhoA, RhoB, and RhoC, are key regulators
of signal transduction in a variety of cellular processes, including regulation of actomyosin …

Cell adhesion and migration are regulated through the concerted action of cytoskeletal
dynamics and adhesion proteins, the activity of which is governed by RhoGTPases. Specific …

Glioblastoma multiforme (GBM) is one of the most common and deadly cancers of the
central nervous system (CNS). It is characterized by the presence of hypoxic regions …

Invadopodia are actin-rich protrusions that degrade the extracellular matrix and are required
for stromal invasion, intravasation, and metastasis. The role of the focal adhesion protein …

The process of intravasation involving transendothelial migration is a key step in metastatic
spread. How the triple cell complex composed of a macrophage, Mena over-expressing …

The initial step of metastasis is the local invasion of tumor cells into the surrounding tissue.
Invadopodia are actin-based protrusions that mediate the matrix degradation necessary for …