Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

Abstract Purpose of Review Glioblastoma remains resistant to most conventional treatments.
Despite scientific advances in the past three decades, there has been a dearth of effective …

Nano-drug delivery strategies have been highlighted in cancer treatment, and much effort
has been made in the optimization of bioavailability, biocompatibility, pharmacokinetics …

Background: Despite significant advances in understanding the molecular pathways of
glioma, translating this knowledge into effective long-term solutions remains a challenge …

The blood-brain barrier (BBB) and blood-tumor barrier (BTB) pose substantial challenges to
efficacious drug delivery for glioblastoma multiforme (GBM), a primary brain tumor with poor …

Ultrasound (US) is a mechanical wave that can penetrate biological tissues and trigger
complex bioeffects. The mechanisms of US in different diagnosis and treatment are different …

The blood–brain barrier (BBB) precisely controls brain microenvironment and neural activity
by regulating substance transport into and out of the brain. However, it severely hinders drug …

Radiotherapy widely applied for local tumor therapy in clinic has been recently reinvigorated
by the discovery that radiotherapy could activate systematic antitumor immune response …

With the groundbreaking progress in nanomedicine, innovative drug delivery systems have
shown rapid development, in which nano-vehicles play a vital role in disease treatment. In …

Recently, the incidence of brain diseases, such as central nervous system degenerative
diseases, brain tumors, and cerebrovascular diseases, has increased. However, the blood …