Lactose is the most commonly used excipient in carrier-based dry powder inhalation (DPI)
formulations. Numerous inhalation therapies have been developed using lactose as a …

Process simulation using mathematical modeling tools is becoming more common in the
pharmaceutical industry. A mechanistic model is a mathematical modeling tool that can …

The theories of aero-and hydrodynamics predict animal movement and device design in air
and water through the computation of lift, drag, and thrust forces. Although models of …

" A particulate flow is one in which a moving fluid interacts with a large number of discrete
solid particles. The category is extraordinarily broad, encompassing everything from …

In powder bed fusion additive manufacturing, the powder feedstock quality is of paramount
importance; as the process relies on thin layers of powder being spread and selectively …

When engineers and scientists encounter the mixing of powders, they enter a subject where
it is often difficult to find bearings. This perspective seeks to address this need by setting out …

This paper presents a numerical study based on the discrete element method (DEM) to
investigate the transverse mixing of wet particles in a rotating drum. The effects of the liquid …

One of the major shortcomings of discrete element modelling (DEM) is the computational
cost required when the number of particles is huge, especially for fine powders and/or …

An experimental investigation was carried out to study the mixing performance of a
laboratory-scale ResonantAcoustic® Mixer (LabRAM). The first part of the study summarizes …

We performed numerical simulations of dry and wet granular flow inside a four-bladed mixer
using the discrete element method (DEM). A capillary force model was incorporated to mimic …