Capsid modifications for targeting and improving the efficacy of AAV vectors
In the past decade, recombinant vectors based on a non-pathogenic parvovirus, the adeno-
associated virus (AAV), have taken center stage as a gene delivery vehicle for the potential …
associated virus (AAV), have taken center stage as a gene delivery vehicle for the potential …
Viral strategies for targeting the central and peripheral nervous systems
Recombinant viruses allow for targeted transgene expression in specific cell populations
throughout the nervous system. The adeno-associated virus (AAV) is among the most …
throughout the nervous system. The adeno-associated virus (AAV) is among the most …
HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex
Nuclear entry of HIV-1 replication complexes through intact nuclear pore complexes is
critical for successful infection. The host protein cleavage-and-polyadenylation-specificity …
critical for successful infection. The host protein cleavage-and-polyadenylation-specificity …
Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells
Manufacturing of recombinant adeno-associated virus (rAAV) viral vectors remains
challenging, with low yields and low full: empty capsid ratios in the harvest. To elucidate the …
challenging, with low yields and low full: empty capsid ratios in the harvest. To elucidate the …
[HTML][HTML] Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges
Microglia have emerged as a critical component of neurodegenerative diseases. Genetic
manipulation of microglia can elucidate their functional impact in disease. In neuroscience …
manipulation of microglia can elucidate their functional impact in disease. In neuroscience …
Small but increasingly mighty: latest advances in AAV vector research, design, and evolution
Recombinant gene delivery vectors derived from naturally occurring or genetically
engineered adeno-associated viruses (AAV) have taken center stage in human gene …
engineered adeno-associated viruses (AAV) have taken center stage in human gene …
[HTML][HTML] Using a barcoded AAV capsid library to select for clinically relevant gene therapy vectors
While gene transfer using recombinant adeno-associated viral (rAAV) vectors has shown
success in some clinical trials, there remain many tissues that are not well transduced …
success in some clinical trials, there remain many tissues that are not well transduced …
Pre-arrayed pan-AAV peptide display libraries for rapid single-round screening
K Börner, E Kienle, LY Huang, J Weinmann, A Sacher… - Molecular therapy, 2020 - cell.com
Display of short peptides on the surface of adeno-associated viruses (AAVs) is a powerful
technology for the generation of gene therapy vectors with altered cell specificities and/or …
technology for the generation of gene therapy vectors with altered cell specificities and/or …
Adeno-associated virus genome interactions important for vector production and transduction
Recombinant adeno-associated virus has emerged as one of the most promising gene
therapy delivery vectors. Development of these vectors took advantage of key features of the …
therapy delivery vectors. Development of these vectors took advantage of key features of the …
The assembly-activating protein promotes stability and interactions between AAV's viral proteins to nucleate capsid assembly
The adeno-associated virus (AAV) vector is a preferred delivery platform for in vivo gene
therapy. Natural and engineered variations of the AAV capsid affect a plurality of phenotypes …
therapy. Natural and engineered variations of the AAV capsid affect a plurality of phenotypes …