Spermatogenesis is a complex process in the testis and is a cornerstone of male infertility.
The abundance of unsaturated fatty acid and high cell division rate make male germs cells …

The germ cell lineage originates early in development and undergoes a series of complex
developmental processes that culminate in the generation of fully matured gametes, the …

Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) have
been shown to differentiate into primordial germ cells (PGCs) but not into spermatogonia …

Gamete failure-derived infertility affects millions of people worldwide; for many patients,
gamete donation by unrelated donors is the only available treatment. Embryonic stem cells …

Infertility is a prevalent condition that has insidious impacts on the infertile individuals, their
families, and society, which extend far beyond the inability to have a biological child …

For some highly endangered species there are too few reproductively capable animals to
maintain adequate genetic diversity, and extraordinary measures are necessary to prevent …

The generation of research-quality, clinically relevant cell types in vitro from human
pluripotent stem cells requires a detailed understanding of the equivalent human cell types …

Our understanding of human germ cell development is limited in large part due to
inaccessibility of early human development to molecular genetic analysis. Pluripotent …

Medical treatments for cancers or other conditions can lead to permanent infertility. Infertility
is an insidious disease that impacts not only the ability to have a biological child but also the …

STUDY QUESTION How did the field of stem cell research develop in the years following the
derivation of the first human embryonic stem cell (hESC) line? SUMMARY ANSWER …