Mass spectrometry–based proteomics turns quantitative
The field of proteomics is built on technologies to analyze large numbers of proteins—ideally
the entire proteome—in the same experiment. Mass spectrometry (MS) has been …
the entire proteome—in the same experiment. Mass spectrometry (MS) has been …
Proteomics by mass spectrometry: approaches, advances, and applications
Mass spectrometry (MS) is the most comprehensive and versatile tool in large-scale
proteomics. In this review, we dissect the overall framework of the MS experiment into its key …
proteomics. In this review, we dissect the overall framework of the MS experiment into its key …
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis
Eukaryotic cells replicate by a complex series of evolutionarily conserved events that are
tightly regulated at defined stages of the cell division cycle. Progression through this cycle …
tightly regulated at defined stages of the cell division cycle. Progression through this cycle …
Quantitative, high-resolution proteomics for data-driven systems biology
Systems biology requires comprehensive data at all molecular levels. Mass spectrometry
(MS)-based proteomics has emerged as a powerful and universal method for the global …
(MS)-based proteomics has emerged as a powerful and universal method for the global …
Quantitative proteomic analysis of histone modifications
Several mechanisms have been proposed for histone marks to exert their functions,
including altering the physical properties of nucleosomes by neutralization of charge via …
including altering the physical properties of nucleosomes by neutralization of charge via …
Proteomics: a pragmatic perspective
The evolution of mass spectrometry–based proteomic technologies has advanced our
understanding of the complex and dynamic nature of proteomes while concurrently …
understanding of the complex and dynamic nature of proteomes while concurrently …
The lysin motif receptor-like kinase (LysM-RLK) CERK1 is a major chitin-binding protein in Arabidopsis thaliana and subject to chitin-induced phosphorylation*♦
EK Petutschnig, AME Jones, L Serazetdinova… - Journal of Biological …, 2010 - ASBMB
Plants detect potential pathogens by sensing microbe-associated molecular patterns via
pattern recognition receptors. In the dicot model plant Arabidopsis, the lysin motif (LysM) …
pattern recognition receptors. In the dicot model plant Arabidopsis, the lysin motif (LysM) …
Interpreting the protein language using proteomics
ON Jensen - Nature reviews Molecular cell biology, 2006 - nature.com
Post-translational modifications define the functional and structural plasticity of proteins in
archaea, prokaryotes and eukaryotes. Multi-site protein modification modulates protein …
archaea, prokaryotes and eukaryotes. Multi-site protein modification modulates protein …
Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue
R Martello, M Leutert, S Jungmichel, V Bilan… - Nature …, 2016 - nature.com
Although protein ADP-ribosylation is involved in diverse biological processes, it has
remained a challenge to identify ADP-ribose acceptor sites. Here, we present an …
remained a challenge to identify ADP-ribose acceptor sites. Here, we present an …
Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level
JMR Danielsen, KB Sylvestersen… - Molecular & Cellular …, 2011 - ASBMB
The covalent attachment of ubiquitin to proteins regulates numerous processes in eukaryotic
cells. Here we report the identification of 753 unique lysine ubiquitylation sites on 471 …
cells. Here we report the identification of 753 unique lysine ubiquitylation sites on 471 …