Cancer‐associated fibroblasts (CAFs) have conflicting roles in the suppression and
promotion of cancer. Current research focuses on targeting the undesirable properties of …

Our increased understanding of how key metabolic pathways are activated and regulated in
malignant cells has identified metabolic vulnerabilities of cancers. Translating this insight to …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a poor
prognosis and limited therapeutic options. Research on the tumor microenvironment (TME) …

Background Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease characterised
by progressive scarring leading to alveolar stiffness, reduced lung capacity, and impeded …

Pancreatic stellate cells (PSCs) are crucial for metabolism and disease progression in
pancreatic ductal adenocarcinoma (PDAC). However, detailed mechanisms of PSCs in …

Cancer‐associated fibroblasts (CAFs) are orchestrators of the pancreatic ductal
adenocarcinoma (PDAC) microenvironment. Previously we described four CAF subtypes …

Pancreatic adenocarcinoma (PDAC) is predicted to become the second leading cause of
cancer deaths by 2030 and this is mostly due to therapy failure. Limited treatment options …

Background. It has been reported that signaling from the nerve growth factor (NGF) pathway
associated with peripheral nerves is able to contribute to perineural invasion (PNI) of …

Pancreatic stellate cells (PSCs) are key to the treatment-refractory desmoplastic phenotype
of pancreatic ductal adenocarcinoma (PDAC) and have received considerable attention as a …

Chronic fibrotic tissue disrupts various organ functions. Despite significant advances in
therapies, mortality and morbidity due to heart failure remain high, resulting in poor quality of …