Fluorinated molecules have a wide range of applications and are used as medicines,
agrochemicals and refrigerants and in smartphone liquid crystal displays, photovoltaic solar …

Fluorinated pyrazoles play an important role in medicinal chemistry, drug discovery,
agrochemistry, coordination chemistry, and organometallic chemistry. Since the early 1990s …

Fluorine has emerged as a “magic element” in medicinal chemistry, crop, and materials
science. 1 Although fluorine is the most abundant halogen in the earth's crust, it is contained …

Molecules bearing fluorine are increasingly prevalent in pharmaceuticals, agrochemicals,
and functional materials. The cyanodifluoromethyl group is unique because its size is closer …

The CF3 group is an omnipresent motif found in many pharmaceuticals, agrochemicals,
catalysts, materials, and industrial chemicals. Despite well‐established trifluoromethylation …

For more than a century, copper has been used as a promoter in cross-coupling reactions of
aryl halides with diverse nucleophiles to construct C–C and C-heteroatom bonds. The …

The introduction of trifluoromethyl groups into organic molecules has attracted great
attention in the past five years. In this review, we describe the recent efforts in the …

A copper-mediated synthesis of 4-(trifluoromethyl) pyrazoles is described. In one step from
readily accessible α, β-alkynic tosylhydrazones, a remarkable domino sequence of …

The isolation, characterization and reactivity of transition metal trifluoromethyl complexes are
fundamental and challenging topics in trifluoromethylation chemistry. We report herein the …

A combined experimental (radical clock, kinetic, Hammett) and computational (DFT, MM)
study of the trifluoromethylation reaction of aryl halides with CuCF3 reveals a nonradical …