A dynamic, supramolecular view on the multivalent interaction between influenza virus and host cell

NJ Overeem, E van der Vries, J Huskens - Small, 2021 - Wiley Online Library
Understanding how influenza viruses traverse the mucus and recognize host cells is critical
for evaluating their zoonotic potential, and for prevention and treatment of the disease. The …

A non-cytotoxic dendrimer with innate and potent anticancer and anti-metastatic activities

S Shao, Q Zhou, J Si, J Tang, X Liu, M Wang… - Nature Biomedical …, 2017 - nature.com
The structural perfection and multivalency of dendrimers have made them useful for
biodelivery and bioactivity via peripheral functionalization and the modulation of core …

Multiscale modeling of protein membrane interactions for nanoparticle targeting in drug delivery

DM Eckmann, RP Bradley, SK Kandy, K Patil… - Current opinion in …, 2020 - Elsevier
Highlights•Computational methods for modeling hydrodynamic factors in nanoparticle
membrane interactions in targeted drug delivery.•Computational frameworks for predicting …

Design principles for super selectivity using multivalent interactions

T Curk, J Dobnikar, D Frenkel - … : Concepts, Research & …, 2018 - Wiley Online Library
Multivalent particles have the ability to form multiple bonds to a substrate. Hence, a
multivalent interaction can be strong, even if the individual bonds are weak. This chapter …

Amplification free detection of SARS-CoV-2 using multi-valent binding

A Roychoudhury, RJ Allen, T Curk, J Farrell… - ACS …, 2022 - ACS Publications
We present the development of electrochemical impedance spectroscopy (EIS)-based
biosensors for sensitive detection of SARS-CoV-2 RNA using multi-valent binding. By …

Molecular Dynamics Simulation of the Nascent Polyethylene Crystallization in Confined Space: Nucleation and Lamella Orientation

S Chen, W Chen, Y Ren, J Sun, J Wang… - Macromolecules, 2022 - ACS Publications
Different nascent structures during polyethylene growth can impact the final polymer
properties. So far, the evolution of the aggregation structure of nascent polyethylene is still …

Molecular dynamics study on the interfacial properties of mixtures of monomers of polyvinylpyrrolidone (PVP)-based battery binders on graphene and graphite …

A Gutiérrez, S Aparicio, A Pekarovicova… - The Journal of …, 2023 - pubs.aip.org
This study investigates the behavior of two different mixtures of monomers of
polyvinylpyrrolidone (PVP)-based battery binders, polyvinylpyrrolidone: polyvinylidene …

Density control over MBD2 receptor-coated surfaces provides superselective binding of hypermethylated DNA

RW Kolkman, S Michel-Souzy… - … applied materials & …, 2022 - ACS Publications
Using the biomarker hypermethylated DNA (hmDNA) for cancer detection requires a
pretreatment to isolate or concentrate hmDNA from nonmethylated DNA. Affinity …

Designing Multivalent Copolymers for Selective Targeting of Multicomponent Surfaces

V Ravnik, U Bren, T Curk - Macromolecules, 2024 - ACS Publications
Selective targeting of membranes with a specific receptor profile is an ongoing challenge in
targeted drug delivery. We investigate the adsorption of copolymers on a multicomponent …

Computational design of probes to detect bacterial genomes by multivalent binding

T Curk, CA Brackley, JD Farrell… - Proceedings of the …, 2020 - National Acad Sciences
Rapid methods for diagnosis of bacterial infections are urgently needed to reduce
inappropriate use of antibiotics, which contributes to antimicrobial resistance. In many rapid …