Dysfunction of the endothelial lining of lesion-prone areas of the arterial vasculature is an
important contributor to the pathobiology of atherosclerotic cardiovascular disease …

Haemodynamic forces influence the functional properties of vascular endothelium.
Endothelial cells (ECs) have a variety of receptors, which sense flow and transmit …

Expert recommendations on the assessment of wall shear stress in human coronary arteries:
existing methodologies, technical considerations, and clinical applications | European Heart …

Understanding the natural history of coronary artery atherosclerosis is necessary to
determine prognosis and prescribe effective therapies. Traditional management of coronary …

Atherosclerosis causes clinical disease through luminal narrowing or by precipitating
thrombi that obstruct blood flow to the heart (coronary heart disease), brain (ischemic …

Cardiovascular diseases (CVD) are the number one cause of morbidity and death
worldwide. As estimated by the WHO, the global death rate from CVD is 31% wherein, a …

Free radicals, reactive oxygen/nitrogen species (ROS/RNS), hydrogen sulphide, and
hydrogen peroxide play an important role in both intracellular and intercellular signaling; …

Most acute coronary syndromes are caused by sudden luminal thrombosis due to
atherosclerotic plaque rupture or erosion. Preventing such an event seems to be the only …

Atherosclerosis is the build-up of fatty deposits in the arteries. Atherosclerosis is the main
underlying cause of cardiovascular diseases and the leading cause of global morbidity and …

Atherosclerosis remains a major cause of morbidity and mortality worldwide, and a thorough
understanding of the underlying pathophysiological mechanisms is crucial for the …