Novel and improved biocatalysts are increasingly sourced from libraries via experimental
screening. The success of such campaigns is crucially dependent on the number of …

In a forest of a hundred thousand trees, no two leaves are alike. Similarly, no two cells in a
genetically identical group are the same. This heterogeneity at the single-cell level has been …

This article reviews the application of electric circuit methods for the analysis of pressure-
driven microfluidic networks with an emphasis on concentration-and flow-dependent …

Harnessing the ability to precisely and reproducibly actuate fluids and manipulate
bioparticles such as DNA, cells, and molecules at the microscale, microfluidics is a powerful …

Nowadays, artificial intelligence (AI) creates numerous promising opportunities in the life
sciences. AI methods can be significantly advantageous for analyzing the massive datasets …

Substantial evidence shows that the heterogeneity of individual cells within a genetically
identical population can be critical to their chance of survival. Methods that use average …

A long-sought milestone in microfluidics research has been the development of integrated
technology for scalable analysis of transcription in single cells. Here we present a fully …

Lab-on-chip technologies are being developed for multiplexed single cell assays.
Impedance offers a simple non-invasive method for counting, identifying and monitoring …

The ability to obtain ideal conditions for well-defined chemical microenvironments and
controlled temporal chemical and/or thermal variations holds promise of high-resolution cell …

It is important to quantify the distribution of behavior amongst a population of individual cells
to reach a more complete quantitative understanding of cellular processes. Improved high …