Gastric cancer (GC) is a heterogeneous disease, often diagnosed at advanced stages, with
a 5-year survival rate of approximately 20%. Despite notable technological advancements in …

Simple Summary The RAGE signaling pathway is associated with many chronic disorders.
One of them may be endometrial cancer (EC). EC is one of the most common gynecologic …

This study describes the identification and target deconvolution of small molecule inhibitors
of oncogenic Yes-associated protein (YAP1)/TAZ activity with potent anti-tumor activity in …

Introduction Guanine nucleotide exchange factors (GEFs) regulate the activation of small
GTPases (G proteins) of the Ras superfamily proteins controlling cellular functions. Ras …

Low‐grade glioma (LGG) poses significant management challenges and has a dismal
prognosis. While immunotherapy has shown significant promise in cancer treatment, its …

Background There exists a critical transition or tip** point during the complex biological
process. Such critical transition is usually accompanied by the catastrophic consequences …

Synthetic lethality (SL) holds significant promise as a targeted cancer therapy by selectively
eliminating tumor cells while sparing normal cells. However, the discovery of SL gene pairs …

Small GTPases are monomeric (approximately 21 kDa) proteins that regulate a number of
biological processes, such as vesicle transport, cell division cycle, cell migration, invasion …

Synthetic lethal (SL) pairs are pairs of genes whose simultaneous loss-of-function results in
cell death, while a damaging mutation of either gene alone does not affect the cell's survival …

This study describes the identification and target deconvolution of novel small molecule
inhibitors of oncogenic YAP1/TAZ activity with potent anti-tumor activity in vivo. A high …