Rational design in photopharmacology with molecular photoswitches
Photopharmacology is an attractive approach for achieving targeted drug action with the use
of light. In photopharmacology, molecular photoswitches are introduced into the structure of …
of light. In photopharmacology, molecular photoswitches are introduced into the structure of …
Time to target the circadian clock for drug discovery
ES Rasmussen, JS Takahashi, CB Green - Trends in biochemical sciences, 2022 - cell.com
The circadian clock is an intracellular timekee** device that drives daily rhythms in diverse
and extensive processes throughout the body. The clock mechanism comprises a core …
and extensive processes throughout the body. The clock mechanism comprises a core …
Mechanistic Basis for Red Light Switching of Azonium Ions
Azonium ions formed by the protonation of tetra-ortho-methoxy-substituted
aminoazobenzenes photoisomerize with red light under physiological conditions. This …
aminoazobenzenes photoisomerize with red light under physiological conditions. This …
Circadian synchrony: sleep, nutrition, and physical activity
The circadian clock in mammals regulates the sleep/wake cycle and many associated
behavioral and physiological processes. The cellular clock mechanism involves a …
behavioral and physiological processes. The cellular clock mechanism involves a …
Ru (II) photocages enable precise control over enzyme activity with red light
The cytochrome P450 family of enzymes (CYPs) are important targets for medicinal
chemistry. Recently, CYP1B1 has emerged as a key player in chemotherapy resistance in …
chemistry. Recently, CYP1B1 has emerged as a key player in chemotherapy resistance in …
A guide to designing photocontrol in proteins: methods, strategies and applications
AC Kneuttinger - Biological Chemistry, 2022 - degruyter.com
Light is essential for various biochemical processes in all domains of life. In its presence
certain proteins inside a cell are excited, which either stimulates or inhibits subsequent …
certain proteins inside a cell are excited, which either stimulates or inhibits subsequent …
Cryptochromes: Photochemical and structural insight into magnetoreception
Cryptochromes (CRYs) function as blue light photoreceptors in diverse physiological
processes in nearly all kingdoms of life. Over the past several decades, they have emerged …
processes in nearly all kingdoms of life. Over the past several decades, they have emerged …
Cryptochromes in mammals: a magnetoreception misconception?
L Zhang, EP Malkemper - Frontiers in Physiology, 2023 - frontiersin.org
Cryptochromes are flavoproteins related to photolyases that are widespread throughout the
plant and animal kingdom. They govern blue light-dependent growth in plants, control …
plant and animal kingdom. They govern blue light-dependent growth in plants, control …
Circadian regulation of liver metabolism: Experimental approaches in human, rodent, and cellular models
LJ Daniels, D Kay, T Marjot… - American Journal of …, 2023 - journals.physiology.org
Circadian rhythms are endogenous oscillations with approximately a 24-h period that allow
organisms to anticipate the change between day and night. Disruptions that desynchronize …
organisms to anticipate the change between day and night. Disruptions that desynchronize …
Chemical biology to dissect molecular mechanisms underlying plant circadian clocks
Circadian clocks regulate the diel rhythmic physiological activities of plants, enabling them
to anticipate and adapt to day–night and seasonal changes. Genetic and biochemical …
to anticipate and adapt to day–night and seasonal changes. Genetic and biochemical …