The greatest obstacle to using drugs to treat brain tumors is the blood‐brain barrier (BBB),
making it difficult for conventional drug molecules to enter the brain. Therefore, how to safely …

ABSTRACT RNA therapeutics comprise a diverse group of oligonucleotide-based drugs
such as antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and short …

Tumor-targeted therapy based on nanoparticles is a popular research direction in the
biomedical field. After decades of research and development, both the passive targeting …

Nucleic acids are emerging as powerful and functional biomaterials due to their molecular
recognition ability, programmability, and ease of synthesis and chemical modification …

The blood–brain barrier (BBB) plays an irreplaceable role in protecting the central nervous
system (CNS) from bloodborne pathogens. However, the BBB complicates the treatment of …

The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSF) are two of
the most complex and sophisticated concierges that defend the central nervous system …

Cancer represents one of the leading causes of morbidity and mortality worldwide, imposing
an urgent need to develop more efficient treatment alternatives. In this respect, much …

Glioma is the most prevalent type of primary brain tumor, and glioblastoma multiforme (GBM)
is the highest and most deadly type of primary central nervous system (CNS) tumor, affecting …

Deoxyribonucleic acid (DNA) is a molecular carrier of genetic information that can be
fabricated into functional nanomaterials in biochemistry and engineering fields. Those DNA …

The development of programmable biomaterials for use in nanofabrication represents a
major advance for the future of biomedicine and diagnostics. Recent advances in structural …