Emerging evidence indicates that liquid–liquid phase separation, the formation of a
condensed molecular assembly within another diluted aqueous solution, is a means for cells …

The synapsins are a family of neuronal phosphoproteins evolutionarily conserved in
invertebrate and vertebrate organisms. Their best-characterised function is to modulate …

α-Synuclein is a major component of the fibrillary lesion known as Lewy bodies and Lewy
neurites that are the pathologic hallmarks of Parkinson's disease (PD). In addition, point …

Neurotransmitter release relies on the regulated fusion of synaptic vesicles (SVs) that are
tightly packed within the presynaptic bouton of neurons. The mechanism by which SVs are …

In presynaptic terminals, synaptic vesicles (SVs) are found in a discrete cluster that includes
a reserve pool that is mobilized during synaptic activity. Synapsins serve as a key protein for …

Membrane vesicle cycling is orchestrated through the combined actions of proteins and
lipids. At neuronal synapses, this orchestration must meet the stringent demands of speed …

Synapsins were the first presynaptic proteins identified and have served as the flagship of
the presynaptic protein field. Here we review recent studies demonstrating that different …

Background Opioid addiction is a critical medical and societal problem characterized by
vulnerability to relapse. Glutamatergic synapses in the nucleus accumbens regulate the …

Many different reagents and methodologies have been utilised for the modification of
synthetic and biological macromolecular systems. In addition, an area of intense research at …

Synapsins (Syns) are phosphoproteins strongly involved in neuronal development and
neurotransmitter release. Three distinct genes SYN1, SYN2 and SYN3, with elevated …