Network models to enhance the translational impact of cross-species studies

JK Brynildsen, K Rajan, MX Henderson… - Nature Reviews …, 2023 - nature.com
Neuroscience studies are often carried out in animal models for the purpose of
understanding specific aspects of the human condition. However, the translation of findings …

Reward and inhibition in obesity and cigarette smoking: Neurobiological overlaps and clinical implications

AV Ely, RR Wetherill - Physiology & behavior, 2023 - Elsevier
Cigarette smoking and obesity are the leading causes of premature morbidity and mortality
and increase the risk of all-cause mortality four-fold when comorbid. Individuals with these …

[HTML][HTML] Association between vmPFC gray matter volume and smoking initiation in adolescents

S **ang, T Jia, C **e, W Cheng, B Chaarani… - Nature …, 2023 - nature.com
Smoking of cigarettes among young adolescents is a pressing public health issue. However,
the neural mechanisms underlying smoking initiation and sustenance during adolescence …

Converging structural and functional evidence for a rat salience network

PJ Tsai, RJ Keeley, SA Carmack, JCM Vendruscolo… - Biological …, 2020 - Elsevier
Background The salience network (SN) is dysregulated in many neuropsychiatric disorders,
including substance use disorder. Though the SN was initially described in humans …

Adolescent nicotine administration increases nicotinic acetylcholine receptor binding and functional connectivity in specific cortico-striatal-thalamic circuits

RJ Keeley, MKE Prillaman, M Scarlata… - Brain …, 2022 - academic.oup.com
Nicotine exposure is associated with regional changes in brain nicotinic acetylcholine
receptors subtype expression patterns as a function of dose and age at the time of exposure …

Intrinsic differences in insular circuits moderate the negative association between nicotine dependence and cingulate-striatal connectivity strength

RJ Keeley, LM Hsu, JK Brynildsen, H Lu… - …, 2020 - nature.com
The development of brain-based biomarkers to assess nicotine dependence severity and
treatment efficacy are essential to improve the current marginally effective treatment …

Nicotine addiction: Translational insights from circuit neuroscience

MJ Scarlata, RJ Keeley, EA Stein - Pharmacology Biochemistry and …, 2021 - Elsevier
Contemporary neuroscience aims to understand how neuronal activity produces internal
processes and observable behavioral states. This aim crucially depends on systems-level …

Estimating Addiction-Related Brain Connectivity by Prior-Embedding Graph Generative Adversarial Networks

C **g, Y Shen, S Zhao, Y Pan… - IEEE Transactions …, 2024 - ieeexplore.ieee.org
The study of nicotine addiction mechanism is of great significance in both nicotine
withdrawal and brain science. The detection of addiction-related brain connectivity using …

Differential effects of alcohol‐drinking patterns on the structure and function of the brain and cognitive performance in young adult drinkers: A pilot study

X Guo, T Yan, M Chen, X Ma, R Li, B Li… - Brain and …, 2022 - Wiley Online Library
Introduction This study was aimed to determine how different patterns of alcohol
consumption drive changes to brain structure and function and their correlation with …

Altered modular segregation of brain networks during the cue-craving task contributes to the disrupted executive functions in internet gaming disorder

WR Zhou, M Wang, H Zheng, MJ Wang… - Progress in Neuro …, 2021 - Elsevier
Background Previous studies have shown that gaming-related cues could induce gaming
cravings and bring about changes in brain activities in subjects with Internet gaming …