Mesocotical dopamine (DA) inputs to the prefrontal cortex (PFC) play a crtical role in normal
cognitive process and neuropsychiatic pathologies. This DA input regulates aspects of …

Dopamine (DA) is one of the major neurotransmitters and participates in a number of
functions such as motor coordination, emotions, memory, reward mechanism …

THREE synaptic proteins, syntaxin, SNAP-25 and synaptobrevin, were recently identified as
targets of clostridial neurotoxins that irreversibly inhibit synaptic vesicle fusion1–4 …

In rat neostriatal neurons, D1 dopamine receptors regulate the activity of cyclic AMP-
dependent protein kinase (PKA) and protein phosphatase 1 (PP1). The influence of these …

Dopaminergic neurons exert a major modulatory effect on the forebrain. Dopamine and
adenosine 3′, 5′-monophosphate–regulated phosphoprotein (32 kilodaltons)(DARPP …

Throughout the brain, postsynaptic neurons release substances from their cell bodies and
dendrites that regulate the strength of the synapses they receive. Diverse chemical …

Neurochemical and morphological evidence has shown that some neurotransmitters or
substances may be released from both synaptic and nonsynaptic sites for diffusion to target …

A PHYSIOLOGICAL role for the dopamine D1 receptor has been difficult to define,
particularly because of its complex pre-and postsynaptic localization in brain areas such as …

The basal ganglia are comprised of the striatum, the external and internal segment of the
globus pallidus (GPe and GPi, respectively), the subthalamic nucleus (STN), and the …

Several pharmacological and neurochemical conditions in rats inducevacuous' ortremulous'
jaw movements. Although the clinical significance of these movements has been a subject of …