The effect of cyclophosphamide on the immune system: implications for clinical cancer therapy
M Ahlmann, G Hempel - Cancer chemotherapy and pharmacology, 2016 - Springer
Cyclophosphamide is an alkylating agent belonging to the group of oxazaphosporines. As
cyclophosphamide is in clinical use for more than 40 years, there is a lot of experience using …
cyclophosphamide is in clinical use for more than 40 years, there is a lot of experience using …
ABC transporter-mediated multidrug-resistant cancer
ATP-binding cassette (ABC) transporters are involved in active pum** of many diverse
substrates through the cellular membrane. The transport mediated by these proteins …
substrates through the cellular membrane. The transport mediated by these proteins …
Anti-SARS-CoV-2 Activity of Andrographis paniculata Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation …
K Sa-Ngiamsuntorn, A Suksatu… - Journal of natural …, 2021 - ACS Publications
The coronaviruses disease 2019 (COVID-19) caused by a novel coronavirus (SARS-CoV-2)
has become a major health problem, affecting more than 50 million people with over one …
has become a major health problem, affecting more than 50 million people with over one …
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
A Daina, O Michielin, V Zoete - Scientific reports, 2017 - nature.com
To be effective as a drug, a potent molecule must reach its target in the body in sufficient
concentration, and stay there in a bioactive form long enough for the expected biologic …
concentration, and stay there in a bioactive form long enough for the expected biologic …
Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update
The presence of multidrug resistance (MDR) in malignant tumors is one of the primary
causes of treatment failure in cancer chemotherapy. The overexpression of the ATP binding …
causes of treatment failure in cancer chemotherapy. The overexpression of the ATP binding …
A novel chemometric method for the prediction of human oral bioavailability
Orally administered drugs must overcome several barriers before reaching their target site.
Such barriers depend largely upon specific membrane transport systems and intracellular …
Such barriers depend largely upon specific membrane transport systems and intracellular …
ATP‐binding cassette (ABC) transporters in cancer: A review of recent updates
The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …
Emergence and spread of antibiotic-resistant foodborne pathogens from farm to table
Antibiotics have been overused and misused for preventive and therapeutic purposes.
Specifically, antibiotics are frequently used as growth promoters for improving productivity …
Specifically, antibiotics are frequently used as growth promoters for improving productivity …
Computational analysis of calculated physicochemical and ADMET properties of protein-protein interaction inhibitors
The modulation of PPIs by low molecular weight chemical compounds, particularly by orally
bioavailable molecules, would be very valuable in numerous disease indications. However …
bioavailable molecules, would be very valuable in numerous disease indications. However …
An overview of the evidence and mechanisms of herb–drug interactions
PS Fasinu, PJ Bouic, B Rosenkranz - Frontiers in pharmacology, 2012 - frontiersin.org
Despite the lack of sufficient information on the safety of herbal products, their use as
alternative and/or complementary medicine is globally popular. There is also an increasing …
alternative and/or complementary medicine is globally popular. There is also an increasing …