Leukocytes can completely reorganize their cytoskeletal architecture within minutes. This
structural plasticity, which facilitates their migration and communicative function, also …

The morphological term 'amoeboid'migration subsumes a number of rather distinct
biophysical modes of cellular locomotion that range from blebbing motility to entirely actin …

T cells are mechanosensitive but the effect of stiffness on their functions is still debated. We
characterize herein how human primary CD4+ T cell functions are affected by stiffness within …

Integrins dynamically equilibrate between three conformational states on cell surfaces. A
bent conformation has a closed headpiece. Two extended conformations contain either a …

Contractile actomyosin bundles, stress fibers, govern key cellular processes including
migration, adhesion, and mechanosensing. Stress fibers are thus critical for developmental …

Due to the use of intra-vital imaging techniques and assays for cell migration into 3D
matrices there has recently been much interest in different modes of tumour cell migration …

In the context of development, tissue homeostasis, immune surveillance, and pathological
conditions such as cancer metastasis and inflammation, migrating amoeboid cells …

T cell activation depends on extracellular ligation of the T cell receptor (TCR) by peptide–
MHC complexes in a synapse between the T cell and an antigen-presenting cell. The …

During trafficking through tissues, T cells fine-tune their motility to balance the extent and
duration of cell-surface contacts versus the need to traverse an entire organ. Here we show …

Spatiotemporal control of leukocyte dynamics within tissues is critical for successful innate
and adaptive immune responses. Homeostatic trafficking and coordinated infiltration into …