An introduction to the endogenous cannabinoid system

HC Lu, K Mackie - Biological psychiatry, 2016 - Elsevier
The endocannabinoid system (ECS) is a widespread neuromodulatory system that plays
important roles in central nervous system development, synaptic plasticity, and the response …

Hippocampal GABAergic inhibitory interneurons

KA Pelkey, R Chittajallu, MT Craig… - Physiological …, 2017 - journals.physiology.org
In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

The endocannabinoid system in guarding against fear, anxiety and stress

B Lutz, G Marsicano, R Maldonado… - Nature Reviews …, 2015 - nature.com
The endocannabinoid (eCB) system has emerged as a central integrator linking the
perception of external and internal stimuli to distinct neurophysiological and behavioural …

Cortical interneurons that specialize in disinhibitory control

HJ Pi, B Hangya, D Kvitsiani, JI Sanders, ZJ Huang… - Nature, 2013 - nature.com
In the mammalian cerebral cortex the diversity of interneuronal subtypes underlies a division
of labour subserving distinct modes of inhibitory control,,,,,,. A unique mode of inhibitory …

CB1 receptor signaling in the brain: extracting specificity from ubiquity

A Busquets-Garcia, J Bains, G Marsicano - Neuropsychopharmacology, 2018 - nature.com
Endocannabinoids (eCBs) are amongst the most ubiquitous signaling molecules in the
nervous system. Over the past few decades, observations based on a large volume of work …

Endocannabinoid signaling and synaptic function

PE Castillo, TJ Younts, AE Chávez, Y Hashimotodani - Neuron, 2012 - cell.com
Endocannabinoids are key modulators of synaptic function. By activating cannabinoid
receptors expressed in the central nervous system, these lipid messengers can regulate …

[HTML][HTML] Cannabinoids and epilepsy

EC Rosenberg, RW Tsien, BJ Whalley, O Devinsky - Neurotherapeutics, 2015 - Elsevier
Cannabis has been used for centuries to treat seizures. Recent anecdotal reports,
accumulating animal model data, and mechanistic insights have raised interest in cannabis …

Cannabinoid type 2 receptors mediate a cell type-specific plasticity in the hippocampus

AV Stempel, A Stumpf, HY Zhang, T Özdoğan… - Neuron, 2016 - cell.com
Endocannabinoids (eCBs) exert major control over neuronal activity by activating
cannabinoid receptors (CBRs). The functionality of the eCB system is primarily ascribed to …

Multiple functions of endocannabinoid signaling in the brain

I Katona, TF Freund - Annual review of neuroscience, 2012 - annualreviews.org
Despite being regarded as a hippie science for decades, cannabinoid research has finally
found its well-deserved position in mainstream neuroscience. A series of groundbreaking …

[HTML][HTML] Endocannabinoid-mediated control of synaptic transmission

M Kano, T Ohno-Shosaku… - Physiological …, 2009 - journals.physiology.org
The discovery of cannabinoid receptors and subsequent identification of their endogenous
ligands (endocannabinoids) in early 1990s have greatly accelerated research on …