Current challenges and opportunities in treating glioblastoma

A Shergalis, A Bankhead III, U Luesakul… - Pharmacological …, 2018 - Elsevier
Glioblastoma multiforme (GBM), the most common and aggressive primary brain tumor, has
a high mortality rate despite extensive efforts to develop new treatments. GBM exhibits both …

Magnetic nanoparticles in cancer therapy and diagnosis

A Farzin, SA Etesami, J Quint, A Memic… - Advanced healthcare …, 2020 - Wiley Online Library
There is urgency for the development of nanomaterials that can meet emerging biomedical
needs. Magnetic nanoparticles (MNPs) offer high magnetic moments and surface‐area‐to …

[HTML][HTML] Magnetite nanoparticles for cancer diagnosis, treatment, and treatment monitoring: recent advances

RA Revia, M Zhang - Materials today, 2016 - Elsevier
The development of nanoparticles (NPs) for use in all facets of oncological disease
detection and therapy has shown great progress over the past two decades. NPs have been …

Stimuli-responsive nano-architecture drug-delivery systems to solid tumor micromilieu: past, present, and future perspectives

HS El-Sawy, AM Al-Abd, TA Ahmed, KM El-Say… - ACS …, 2018 - ACS Publications
The microenvironment characteristics of solid tumors, renowned as barriers that harshly
impeded many drug-delivery approaches, were precisely studied, investigated, categorized …

[HTML][HTML] Nanocarrier-based drug combination therapy for glioblastoma

M Zhao, D van Straten, MLD Broekman, V Préat… - Theranostics, 2020 - ncbi.nlm.nih.gov
The current achievements in treating glioblastoma (GBM) patients are not sufficient because
many challenges exist, such as tumor heterogeneity, the blood brain barrier, glioma stem …

Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

CD Spicer, C Jumeaux, B Gupta… - Chemical Society …, 2018 - pubs.rsc.org
Peptide–and protein–nanoparticle conjugates have emerged as powerful tools for
biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In …

[HTML][HTML] Progress and perspectives on targeting nanoparticles for brain drug delivery

H Gao - Acta Pharmaceutica Sinica B, 2016 - Elsevier
Due to the ability of the blood–brain barrier (BBB) to prevent the entry of drugs into the brain,
it is a challenge to treat central nervous system disorders pharmacologically. The …

Metallic nanoparticles as drug delivery system for the treatment of cancer

N Desai, M Momin, T Khan, S Gharat… - Expert opinion on …, 2021 - Taylor & Francis
Introduction The targeted delivery of anticancer agents to tumor is a major challenge
because most of the drugs show off-target effect resulting in nonspecific cell death …

Glioblastoma: current status, emerging targets, and recent advances

A Thakur, C Faujdar, R Sharma, S Sharma… - Journal of Medicinal …, 2022 - ACS Publications
Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …

[HTML][HTML] Recent advancements of magnetic nanomaterials in cancer therapy

S Mukherjee, L Liang, O Veiseh - Pharmaceutics, 2020 - mdpi.com
Magnetic nanomaterials belong to a class of highly-functionalizable tools for cancer therapy
owing to their intrinsic magnetic properties and multifunctional design that provides a …