[HTML][HTML] Drug repurposing in oncology: Compounds, pathways, phenotypes and computational approaches for colorectal cancer
The strategy of using existing drugs originally developed for one disease to treat other
indications has found success across medical fields. Such drug repurposing promises faster …
indications has found success across medical fields. Such drug repurposing promises faster …
Large-scale prediction and testing of drug activity on side-effect targets
Discovering the unintended 'off-targets' that predict adverse drug reactions is daunting by
empirical methods alone. Drugs can act on several protein targets, some of which can be …
empirical methods alone. Drugs can act on several protein targets, some of which can be …
Quo vadis blood protein adductomics?
G Sabbioni, BW Day - Archives of toxicology, 2022 - Springer
Chemicals are measured regularly in air, food, the environment, and the workplace.
Biomonitoring of chemicals in biological fluids is a tool to determine the individual exposure …
Biomonitoring of chemicals in biological fluids is a tool to determine the individual exposure …
Biomonitoring human albumin adducts: the past, the present, and the future
G Sabbioni, RJ Turesky - Chemical research in toxicology, 2017 - ACS Publications
Serum albumin (Alb) is the most abundant protein in blood plasma. Alb reacts with many
carcinogens and/or their electrophilic metabolites. Studies conducted over 20 years ago …
carcinogens and/or their electrophilic metabolites. Studies conducted over 20 years ago …
Hepatotoxic evaluation of toosendanin via biomarker quantification and pathway map** of large-scale chemical proteomics
Y Zhuo, Y Zhang, M Li, H Wu, S Gong, X Hu… - Food and Chemical …, 2021 - Elsevier
Drug-induced liver injury (DILI) is a major side effect, sometimes can't be exactly evaluated
by current approaches partly as the covalent modification of drug or its reactive metabolites …
by current approaches partly as the covalent modification of drug or its reactive metabolites …
Animal models of idiosyncratic drug reactions
W Ng, ARM Lobach, X Zhu, X Chen, F Liu… - Advances in …, 2012 - Elsevier
If we could predict and prevent idiosyncratic drug reactions (IDRs) it would have a profound
effect on drug development and therapy. Given our present lack of mechanistic …
effect on drug development and therapy. Given our present lack of mechanistic …
Detection of drug bioactivation in vivo: mechanism of nevirapine–albumin conjugate formation in patients
X Meng, A Howarth, CJ Earnshaw… - Chemical Research …, 2013 - ACS Publications
The non-nucleoside reverse transcriptase inhibitor nevirapine (NVP) is widely used for the
treatment of human immunodeficiency virus type 1 (HIV-1), particularly in develo** …
treatment of human immunodeficiency virus type 1 (HIV-1), particularly in develo** …
Evidence for nevirapine bioactivation in man: searching for the first step in the mechanism of nevirapine toxicity
U Caixas, AMM Antunes, AT Marinho, ALA Godinho… - Toxicology, 2012 - Elsevier
Despite its efficacy, including in the prevention of vertical transmission, the antiretroviral
nevirapine is associated with severe idiosyncratic hepatotoxicity and skin rash. The …
nevirapine is associated with severe idiosyncratic hepatotoxicity and skin rash. The …
Hepatocyte spheroids as a competent in vitro system for drug biotransformation studies: nevirapine as a bioactivation case study
The development of metabolically competent in vitro models is of utmost importance for
predicting adverse drug reactions, thereby preventing attrition-related economical and …
predicting adverse drug reactions, thereby preventing attrition-related economical and …
Biomarker-based drug safety assessment in the age of systems pharmacology: from foundational to regulatory science
Improved biomarker-based assessment of drug safety is needed in drug discovery and
development as well as regulatory evaluation. However, identifying drug safety-related …
development as well as regulatory evaluation. However, identifying drug safety-related …