Electric field (EF) stimulation can play a vital role in eliciting appropriate stem cell response.
Such an approach is recently being established to guide stem cell differentiation through …

After decades of directed research, no effective regenerative therapy is currently available to
repair the injured human heart. The epicardium, a layer of mesothelial tissue that envelops …

The elucidation of factors that activate the regeneration of the adult mammalian heart is of
major scientific and therapeutic importance. Here we found that epicardial cells contain a …

In mammals, enlargement of the heart during embryonic development is primarily
dependent on the increase in cardiomyocyte numbers. Shortly after birth, however …

Long noncoding RNAs (lncRNAs) are often expressed in a development-specific manner,
yet little is known about their roles in lineage commitment. Here, we identified Braveheart …

We recently identified a brief time period during postnatal development when the
mammalian heart retains significant regenerative potential after amputation of the ventricular …

Cardiovascular disease is a leading cause of death worldwide. The limited capability of
heart tissue to regenerate has prompted methodological developments for creating de novo …

In contrast to lower vertebrates, the mammalian heart has limited capacity to regenerate after
injury in part due to ineffective reactivation of cardiomyocyte proliferation. We show that the …

Cardiovascular regenerative therapies are pursued on both basic and translational levels.
Although efficacy and value of cell therapy for myocardial regeneration can be debated …

Colony-forming units–fibroblast (CFU-Fs), analogous to those giving rise to bone marrow
(BM) mesenchymal stem cells (MSCs), are present in many organs, although the …