Transmembrane proteins comprise~ 30% of the mammalian proteome, mediating
metabolism, signalling, transport and many other functions required for cellular life. The …

The lipid raft hypothesis postulates that lipid–lipid interactions can laterally organize
biological membranes into domains of distinct structures, compositions, and functions. This …

During T cell activation, the transmembrane adaptor protein LAT (linker for activation of T
cells) forms biomolecular condensates with Grb2 and Sos1, facilitating signaling. LAT has …

Cellular membranes are formed from a chemically diverse set of lipids present in various
amounts and proportions. A high lipid diversity is universal in eukaryotes and is seen from …

Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct
subcompartments that differ in their biophysical properties and composition. A large number …

At least 150 human proteins are glycosylphosphatidylinositol-anchored proteins (GPI-APs).
The protein moiety of GPI-APs lacking transmembrane domains is anchored to the plasma …

Very-long-chain fatty acids (ie, fatty acids with more than 18 carbon atoms; VLCFA) are
important molecules that play crucial physiological and structural roles in plants. VLCFA are …

Cell surface transmembrane receptors often form nanometer-to micrometer-scale clusters to
initiate signal transduction in response to environmental cues. Extracellular ligand …

The plasma membrane (PM) is the biological membrane that separates the interior of all
cells from the outside. The PM is constituted of a huge diversity of proteins and lipids. In this …

Eukaryotic plasma membranes are compartmentalized into functional lateral domains,
including lipid-driven membrane rafts. Rafts are involved in most plasma membrane …