Recent advancements on benzimidazole: A versatile scaffold in medicinal chemistry
ZMM Alzhrani, MM Alam… - Mini Reviews in Medicinal …, 2022 - ingentaconnect.com
Benzimidazole is a nitrogen-containing fused heterocycle which has been extensively
explored in medicinal chemistry. Benzimidizole nucleus has been found to possess various …
explored in medicinal chemistry. Benzimidizole nucleus has been found to possess various …
Recent efforts in the discovery of urease inhibitor identifications
WQ Song, ML Liu, SY Li, ZP **ao - Current Topics in Medicinal …, 2022 - ingentaconnect.com
Urease is an attractive drug target for designing anti-infective agents against pathogens
such as Helicobacter pylori, Proteus mirabilis, and Ureaplasma urealyticum. In the past …
such as Helicobacter pylori, Proteus mirabilis, and Ureaplasma urealyticum. In the past …
Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study
Voglibose and acarbose are distinguished α-glucosidase inhibitors used for controlling of
diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also …
diabetes mellitus. Unfortunately, these distinguished and clinically used inhibitors have also …
Benzimidazole bearing thiosemicarbazone derivatives act as potent α-amylase and α-glucosidase inhibitors; synthesis, bioactivity screening and molecular docking …
Diabetes mellitus is one of the most chronic metabolic diseases. In the past few years, our
research group has synthesized and evaluated libraries of heterocyclic analogs against α …
research group has synthesized and evaluated libraries of heterocyclic analogs against α …
Synthesis, in vitro urease inhibitory potential and molecular docking study of benzofuran-based-thiazoldinone analogues
In continuation of our work on enzyme inhibition, the benzofuran-based-thiazoldinone
analogues (1–14) were synthesized, characterized by HREI-MS, 1H and 13CNMR and …
analogues (1–14) were synthesized, characterized by HREI-MS, 1H and 13CNMR and …
Design and synthesis of novel nitrothiazolacetamide conjugated to different thioquinazolinone derivatives as anti-urease agents
The present article describes the design, synthesis, in vitro urease inhibition, and in silico
molecular docking studies of a novel series of nitrothiazolacetamide conjugated to different …
molecular docking studies of a novel series of nitrothiazolacetamide conjugated to different …
Synthesis of indole-based-thiadiazole derivatives as a potent inhibitor of α-glucosidase enzyme along with in silico study
Abstract A series of nineteen (1–19) indole-based-thiadiazole derivatives were synthesized,
characterized by 1 HNMR, 13 C NMR, MS, and screened for α-glucosidase inhibition. All …
characterized by 1 HNMR, 13 C NMR, MS, and screened for α-glucosidase inhibition. All …
Synthesis, in vitro inhibitor screening, structure–activity relationship, and molecular dynamic simulation studies of novel thioquinoline derivatives as potent α …
New series of thioquinoline structures bearing phenylacetamide 9a–p were designed,
synthesized and the structure of all derivatives was confirmed using different spectroscopic …
synthesized and the structure of all derivatives was confirmed using different spectroscopic …
Synthesis, in-vitro and in-silico studies of triazinoindole bearing bis-Schiff base as β-glucuronidase inhibitors
Triazinoindole bearing bis-Schiff base analogs (1–20) were synthesized by triazinoindole-
thione ring formation, triazinoindole-thiol-phenylethanone, followed by triazinoindole bis …
thione ring formation, triazinoindole-thiol-phenylethanone, followed by triazinoindole bis …
New triazinoindole bearing benzimidazole/benzoxazole hybrids analogs as potent inhibitors of urease: synthesis, in vitro analysis and molecular docking studies
Twenty-four analogs based on triazinoindole bearing benzimidazole/benzoxazole moieties
(1–25) were synthesized. Utilizing a variety of spectroscopic methods, including 1H-, 13C …
(1–25) were synthesized. Utilizing a variety of spectroscopic methods, including 1H-, 13C …