Ribosomal proteins (r-proteins) are abundant, highly conserved, and multifaceted cellular
proteins in all domains of life. Most r-proteins have RNA-binding properties and can form …

Ribosome assembly is one of the most fundamental processes of gene expression and has
served as a playground for investigating the molecular mechanisms of how protein–RNA …

Universally conserved factors from NusG family bind at the upstream fork junction of
transcription elongation complexes and modulate RNA synthesis in response to translation …

Bacterial ribosomal RNAs are synthesized by a dedicated, conserved transcription-
elongation complex that transcribes at high rates, shields RNA polymerase from premature …

Transcription is a discontinuous process, where each nucleotide incorporation cycle offers a
decision between elongation, pausing, halting, or termination. Many cis-acting regulatory …

Discovery of antibiotics of a novel mode of action is highly required in the fierce battlefield
with multi-drug resistant bacterial infections. Previously we have validated the protein …

In every cell from bacteria to mammals, NusG-like proteins bind transcribing RNA
polymerase to modulate the rate of nascent RNA synthesis and to coordinate it with …

Cold-stress in Escherichia coli induces de novo synthesis of translation initiation factors IF1,
IF2 and IF3 while ribosome synthesis and assembly slow down. Consequently, the …

Ribosome biogenesis occurs co-transcriptionally and entails rRNA folding, ribosomal
protein binding, rRNA processing, and rRNA modification. In most bacteria, the 16S, 23S …

The coordination of bacterial genomic transcription involves an intricate network of
interdependent genes encoding nucleoid-associated proteins (NAPs), DNA …