[HTML][HTML] Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

J Lloyd-Price, C Arze, AN Ananthakrishnan… - Nature, 2019 - nature.com
Inflammatory bowel diseases, which include Crohn's disease and ulcerative colitis, affect
several million individuals worldwide. Crohn's disease and ulcerative colitis are complex …

Best practices for analysing microbiomes

R Knight, A Vrbanac, BC Taylor, A Aksenov… - Nature Reviews …, 2018 - nature.com
Complex microbial communities shape the dynamics of various environments, ranging from
the mammalian gastrointestinal tract to the soil. Advances in DNA sequencing technologies …

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

L Zhao, F Zhang, X Ding, G Wu, YY Lam, X Wang, H Fu… - Science, 2018 - science.org
The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from
carbohydrate fermentation, and deficiency in SCFA production is associated with type 2 …

Species-level functional profiling of metagenomes and metatranscriptomes

EA Franzosa, LJ McIver, G Rahnavard, LR Thompson… - Nature …, 2018 - nature.com
Functional profiles of microbial communities are typically generated using comprehensive
metagenomic or metatranscriptomic sequence read searches, which are time-consuming …

Diet rapidly and reproducibly alters the human gut microbiome

LA David, CF Maurice, RN Carmody, DB Gootenberg… - Nature, 2014 - nature.com
Long-term dietary intake influences the structure and activity of the trillions of
microorganisms residing in the human gut,,,,, but it remains unclear how rapidly and …

Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences

MGI Langille, J Zaneveld, JG Caporaso… - Nature …, 2013 - nature.com
Profiling phylogenetic marker genes, such as the 16S rRNA gene, is a key tool for studies of
microbial communities but does not provide direct evidence of a community's functional …

The integrative human microbiome project

HMP Integrative, LM Proctor, HH Creasy… - …, 2019 - ui.adsabs.harvard.edu
Abstract The NIH Human Microbiome Project (HMP) has been carried out over ten years and
two phases to provide resources, methods, and discoveries that link interactions between …

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

G Den Besten, K Van Eunen, AK Groen, K Venema… - Journal of lipid …, 2013 - ASBMB
Short-chain fatty acids (SCFAs), the end products of fermentation of dietary fibers by the
anaerobic intestinal microbiota, have been shown to exert multiple beneficial effects on …

The healthy human microbiome

J Lloyd-Price, G Abu-Ali, C Huttenhower - Genome medicine, 2016 - Springer
Humans are virtually identical in their genetic makeup, yet the small differences in our DNA
give rise to tremendous phenotypic diversity across the human population. By contrast, the …

Structure, function and diversity of the healthy human microbiome

nature, 2012 - nature.com
Studies of the human microbiome have revealed that even healthy individuals differ
remarkably in the microbes that occupy habitats such as the gut, skin and vagina. Much of …