In the past decade RNA-based therapies such as small interfering RNA (siRNA) and
messenger RNA (mRNA) have emerged as new and ground-breaking therapeutic agents for …

Aerosol therapy is a key modality for drug delivery to the lungs of respiratory disease
patients. Aerosol therapy improves therapeutic effects by directly targeting diseased lung …

Non-small cell lung cancer (NSCLC) is one of the major causes of cancer-related mortality
globally. Despite the availability of therapeutic options, the improvement in patient survival is …

MicroRNAs that are overexpressed in cystic fibrosis (CF) bronchial epithelial cells (BEC)
negatively regulate CFTR and nullify the beneficial effects of CFTR modulators. We …

Develo** new effective treatment strategies to overcome the rise in multi-drug resistant
tuberculosis cases (MDR-TB) represents a global challenge. A host-directed therapy (HDT) …

Background: Mesenchymal stem/stromal cells (MSCs) have demonstrated promise in
pathogenic acute respiratory distress syndrome models and are advancing to clinical …

The last years have witnessed an impressive development of material sciences following the
burst of nanotechnology, which has greatly contributed to the development of nonviral gene …

Background Aerosol drug delivery during high flow nasal oxygen (HFNO) and invasive
mechanical ventilation (IMV) are key respiratory care strategies available for the treatment of …

Introduction: Active pharmaceutical ingredients (APIs) are evolving from low-molecular-
weight drugs to peptide-, protein-, gene-, oligonucleotide-and cell-based drugs. Therefore …

Cyclodextrins (CDs) have long occupied a prominent position in most pharmaceutical
laboratories as “off-the-shelve” tools to manipulate the pharmacokinetics of a broad range of …