[HTML][HTML] Origin of antibiotics and antibiotic resistance, and their impacts on drug development: A narrative review

G Muteeb, MT Rehman, M Shahwan, M Aatif - Pharmaceuticals, 2023 - mdpi.com
Antibiotics have revolutionized medicine, saving countless lives since their discovery in the
early 20th century. However, the origin of antibiotics is now overshadowed by the alarming …

[HTML][HTML] Role of Efflux Pumps on Antimicrobial Resistance in Pseudomonas aeruginosa

AB Lorusso, JA Carrara, CDN Barroso, FF Tuon… - International journal of …, 2022 - mdpi.com
Antimicrobial resistance is an old and silent pandemic. Resistant organisms emerge in
parallel with new antibiotics, leading to a major global public health crisis over time …

The Diversity of Escherichia coli Pathotypes and Vaccination Strategies against This Versatile Bacterial Pathogen

P Pokharel, S Dhakal, CM Dozois - Microorganisms, 2023 - mdpi.com
Escherichia coli (E. coli) is a gram-negative bacillus and resident of the normal intestinal
microbiota. However, some E. coli strains can cause diseases in humans, other mammals …

Accelerated spread of antibiotic resistance genes (ARGs) induced by non-antibiotic conditions: roles and mechanisms

X Shi, Y **a, W Wei, BJ Ni - Water Research, 2022 - Elsevier
The global spread of antibiotic resistance genes (ARGs) has wreaked havoc with the
treatment efficiency of antibiotics and, ultimately, anti-microbial chemotherapy, and has been …

[HTML][HTML] Antibiotic pollution and associated antimicrobial resistance in the environment

P Barathe, K Kaur, S Reddy, V Shriram… - Journal of Hazardous …, 2024 - Elsevier
The widespread and injudicious usage of antibiotics to contain pathogenic microbial
infections, coupled with inadequate treatment of wastes containing non-metabolized …

Antimicrobial resistance in bacteria: mechanisms, evolution, and persistence

E Christaki, M Marcou, A Tofarides - Journal of molecular evolution, 2020 - Springer
In recent years, we have seen antimicrobial resistance rapidly emerge at a global scale and
spread from one country to the other faster than previously thought. Superbugs and …

Antibiotic resistance: a rundown of a global crisis

B Aslam, W Wang, MI Arshad, M Khurshid… - Infection and drug …, 2018 - Taylor & Francis
The advent of multidrug resistance among pathogenic bacteria is imperiling the worth of
antibiotics, which have previously transformed medical sciences. The crisis of antimicrobial …

Antibiotics in the soil environment—degradation and their impact on microbial activity and diversity

M Cycoń, A Mrozik, Z Piotrowska-Seget - Frontiers in microbiology, 2019 - frontiersin.org
Antibiotics play a key role in the management of infectious diseases in humans, animals,
livestock, and aquacultures all over the world. The release of increasing amount of …

Soil and human health: current status and future needs

EC Brevik, L Slaughter, BR Singh… - Air, Soil and Water …, 2020 - journals.sagepub.com
Soil influences human health in a variety of ways, with human health being linked to the
health of the soil. Historically, emphasis has been placed on the negative impacts that soils …

Drivers of irrational use of antibiotics in Europe

A Machowska, C Stålsby Lundborg - International journal of …, 2019 - mdpi.com
The unnecessary use of antibiotics and concomitant rapid growth of antibiotic resistance
(ABR) is a widely acknowledged threat to global health, development, and sustainability …