Chemokines and their receptors play an important role in the recruitment, activation and
differentiation of immune cells. The chemokine receptor, CXCR3, and its ligands, CXCL9 …

Simple Summary The immune response against cancer is generated by effector T cells,
among them cytotoxic CD8+ T cells that destroy cancer cells and helper CD4+ T cells that …

Infiltration of regulatory T (Treg) cells, an immunosuppressive population of CD4+ T cells,
into solid cancers represents a barrier to cancer immunotherapy. Chemokine receptors are …

CXC chemokines are involved in chemotaxis, regulation of cell growth, induction of
apoptosis and modulation of angiostatic effects. CXCL9, CXCL10, CXCL11, CXCL4 and its …

First thought to orchestrate exclusively leukocyte trafficking, chemokines are now
acknowledged for their multiple roles in the regulation of cell proliferation, differentiation …

Chemokines are a family of soluble cytokines that act as chemoattractants to guide the
migration of cells, in particular of immune cells. However, chemokines are also involved in …

Background: Tumoural infiltration of T lymphocytes is determined by local patterns of specific
chemokine expression. In this report, we examined the roles of CCL4 and CCL20 in the …

Esophageal squamous cell carcinoma (ESCC) is a very common malignant tumor with poor
prognosis in China. Chemokines secreted by tumors are pivotal for the accumulation of …

The process of cancer immunoediting generates a repertoire of cancer cells that can persist
in immune-competent hosts. In its most complex form, this process begins with the …

Abstract The interleukin-17 (IL-17) family is a relatively new family of cytokines consisting of
6 related factors (IL-17A–IL-17F), while the receptor family consists of 5 members: IL-17RA …