Stanniocalcin 2 (STC2): a universal tumour biomarker and a potential therapeutical target

S Qie, N Sang - Journal of Experimental & Clinical Cancer Research, 2022 - Springer
Abstract Stanniocalcin 2 (STC2) is a glycoprotein which is expressed in a broad spectrum of
tumour cells and tumour tissues derived from human breast, colorectum, stomach …

Stanniocalcin 1 promotes lung metastasis of breast cancer by enhancing EGFR–ERK–S100A4 signaling

A Liu, Y Li, S Lu, C Cai, F Zou, X Meng - Cell Death & Disease, 2023 - nature.com
Lung metastasis is the leading cause of breast cancer-related death. The tumor
microenvironment contributes to the metastatic colonization of tumor cells in the lungs …

Expression, function and clinical application of stanniocalcin‐1 in cancer

F Zhao, G Yang, M Feng, Z Cao, Y Liu… - Journal of Cellular …, 2020 - Wiley Online Library
The glycoprotein stanniocalcin‐1 functions as a regulatory endocrine hormone that
maintains the balance of calcium and phosphorus in bony fish and as a paracrine/autocrine …

Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer

F Lin, X Li, X Wang, H Sun, Z Wang, X Wang - Journal of Experimental & …, 2022 - Springer
Abstract Background Stanniocalcin 1 (STC1) plays an integral role in ovarian cancer (OC).
However, the functional role of STC1 in metastasis, lipid metabolism and cisplatin (DDP) …

Role of stanniocalcin‑1 in breast cancer

F Chen, Z Zhang, F Pu - Oncology Letters, 2019 - spandidos-publications.com
Breast cancer is a highly heterogeneous disease consisting of five disease subtypes with
distinct histological characteristics, clinical behaviors and prognostic features. Stanniocalcin …

STC1 is a novel biomarker associated with immune characteristics and prognosis of bladder cancer

J Sun, X Wei, J You, W Yue, J Ouyang… - International journal of …, 2021 - Taylor & Francis
Background Stanniocalcin-1 (STC1) is a well-studied oncogene that promotes different
types of cancer progression. However, the expression status of STC1, the values of STC1 on …

Breast Cancer Cells Reprogram the Oncogenic lncRNAs/mRNAs Coexpression Networks in Three-Dimensional Microenvironment

SI Nuñez-Olvera, L Aguilar-Arnal… - Cells, 2022 - mdpi.com
Organotypic three-dimensional (3D) cell cultures more accurately mimic the characteristics
of solid tumors in vivo in comparison with traditional two-dimensional (2D) monolayer cell …

Integrins as the pivotal regulators of cisplatin response in tumor cells

A Nasimi Shad, M Moghbeli - Cell Communication and Signaling, 2024 - Springer
Cisplatin (CDDP) is a widely used first-line chemotherapeutic drug in various cancers.
However, CDDP resistance is frequently observed in cancer patients. Therefore, it is …

Stanniocalcin-1 in tumor immunity: acts via macrophages

L Wang, J Wang, W Qiang, W Ge - Frontiers in Immunology, 2024 - frontiersin.org
Tumor immune escape has become a research hotspot in the field of cancer
immunotherapy. Tumor-associated macrophages (TAMs) are the key component of tumor …

STC2 modulates ERK1/2 signaling to suppress adipogenic differentiation of human bone marrow mesenchymal stem cells

B Ma, X Xu, S He, J Zhang, X Wang, P Wu, J Liu… - Biochemical and …, 2020 - Elsevier
Abstract Stanniocalcin-2 (STC2) is a glycoprotein that has been found to play key roles in
the regulation of cancer, diabetes mellitus, and osteogenesis. Herein we sought to extend …