Epigenetics has long been recognized as a significant field in biology and is defined as the
investigation of any alteration in gene expression patterns that is not attributed to changes in …

Epigenetic mechanisms, which involve DNA and histone modifications, result in the
heritable silencing of genes without a change in their coding sequence. The study of human …

Ovarian cancer is the most lethal of all gynecological cancers, and there is an urgent unmet
need to develop new therapies. Epithelial ovarian cancer (EOC) is characterized by an …

Reversal of promoter DNA hypermethylation and associated gene silencing is an attractive
cancer therapy approach. The DNA methylation inhibitors decitabine and azacitidine are …

Azacytidine was first synthesized almost 40 years ago. It was demonstrated to have a wide
range of anti-metabolic activities when tested against cultured cancer cells and to be an …

Recently, we and others identified the microRNA miR-34a as a target of the tumor
suppressor gene product p53. Ectopic miR-34a induces a G1 cell cycle arrest, senescence …

Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an essential regulator of
DNA methylation that is highly expressed in many cancers. Here, we use transgenic …

Vitamin C deficiency is found in patients with cancer and might complicate various therapy
paradigms. Here we show how this deficiency may influence the use of DNA …

For centuries, the black seed (Nigella sativa) herb and oil have been used in Asia, Middle
East and Africa to promote health and fight disease. Thymoquinone (TQ), the most abundant …

The comet assay is a sensitive and rapid method for DNA strand break detection in
individual cells, and the year 2009 represents the 25th anniversary of the first description of …