Growth rate maximization is an important fitness strategy for microbes. However, the wide
distribution of slow-growing oligotrophic microbes in ecosystems suggests that rapid growth …

The ribosome is an ancient molecular fossil that provides a telescope to the origins of life.
Made from RNA and protein, the ribosome translates mRNA to coded protein in all living …

INTRODUCTION Microbial populations display heterogeneous gene expression profiles that
result in phenotypic differences between individual bacteria. This diversity can allow …

Dysbiosis of the gut microbiome has been associated with the pathogenesis of colorectal
cancer (CRC). We profiled the microbiome of gut mucosal tissues from 18 CRC patients and …

Probiotics, live microorganisms that, when administered in adequate amounts, confer a
health benefit on the host, offer an alternative to antibiotics and have become popular …

When conditions change, unicellular organisms rewire their metabolism to sustain cell
maintenance and cellular growth. Such rewiring may be understood as resource re …

Growing cells coordinate protein translation with metabolic rates. Central to this coordination
is ribosome production. Ribosomes drive cell growth, but translation of ribosomal proteins …

How innate T cells (ITC), including invariant natural killer T (iNKT) cells, mucosal-associated
invariant T (MAIT) cells, and γδ T cells, maintain a poised effector state has been unclear …

Microbial communities are continuously exposed to unpredictable changes in their
environment. To thrive in such dynamic habitats, microorganisms have developed the ability …

To respond to fluctuating conditions, microbes typically need to synthesize novel proteins.
As this synthesis relies on sufficient biosynthetic precursors, microbes must devise effective …