Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets

S Zhang, X **ao, Y Yi, X Wang, L Zhu, Y Shen… - Signal transduction and …, 2024‏ - nature.com
Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring
clonal advantage as the initial event. However, despite pervasive somatic mutations and …

Microbiome and cancer

N Cullin, CA Antunes, R Straussman… - Cancer cell, 2021‏ - cell.com
The human microbiome constitutes a complex multikingdom community that symbiotically
interacts with the host across multiple body sites. Host-microbiome interactions impact …

Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study

Y Long, L Tang, Y Zhou, S Zhao, H Zhu - BMC medicine, 2023‏ - Springer
Background Evidence from observational studies and clinical trials suggests that the gut
microbiota is associated with cancer. However, the causal association between gut …

[HTML][HTML] A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors

AB Dohlman, J Klug, M Mesko, IH Gao, SM Lipkin… - Cell, 2022‏ - cell.com
Fungal microorganisms (mycobiota) comprise a small but immunoreactive component of the
human microbiome, yet little is known about their role in human cancers. Pan-cancer …

The genomic landscape of 2,023 colorectal cancers

AJ Cornish, AJ Gruber, B Kinnersley, D Chubb… - Nature, 2024‏ - nature.com
Colorectal carcinoma (CRC) is a common cause of mortality, but a comprehensive
description of its genomic landscape is lacking,,,,,,–. Here we perform whole-genome …

Microbiota in tumors: from understanding to application

Y **e, F **e, X Zhou, L Zhang, B Yang… - Advanced …, 2022‏ - Wiley Online Library
Microbes with complex functions have been found to be a potential component in tumor
microenvironments. Due to their low biomass and other obstacles, intratumor microbiota is …

Intracellular bacteria in cancer—prospects and debates

L Schorr, M Mathies, E Elinav, J Puschhof - npj Biofilms and …, 2023‏ - nature.com
Recent evidence suggests that some human cancers may harbor low-biomass microbial
ecosystems, spanning bacteria, viruses, and fungi. Bacteria, the most-studied kingdom in …

The heightened importance of the microbiome in cancer immunotherapy

C Villemin, A Six, BA Neville, TD Lawley… - Trends in …, 2023‏ - cell.com
The human microbiome is recognized as a key factor in health and disease. This has been
further corroborated by identifying changes in microbiome composition and function as a …

Multi-omic approaches for host-microbiome data integration

A Chetty, R Blekhman - Gut Microbes, 2024‏ - Taylor & Francis
The gut microbiome interacts with the host through complex networks that affect physiology
and health outcomes. It is becoming clear that these interactions can be measured across …

Hydrogen sulfide produced by the gut microbiota impairs host metabolism via reducing GLP-1 levels in male mice

Q Qi, H Zhang, Z **, C Wang, M **a, B Chen, B Lv… - Nature …, 2024‏ - nature.com
Dysbiosis of the gut microbiota has been implicated in the pathogenesis of metabolic
syndrome (MetS) and may impair host metabolism through harmful metabolites. Here, we …