Schwann cells develop from the neural crest in a well-defined sequence of events. This
involves the formation of the Schwann cell precursor and immature Schwann cells, followed …

Although it is broadly agreed that the improved treatment of patients with cancer will depend
on a deeper molecular understanding of the underlying pathogenesis, only a few examples …

When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger
a rich network of signalling pathways, culminating in responses ranging from cell division to …

Functional recovery from peripheral nerve injury and repair depends on a multitude of
factors, both intrinsic and extrinsic to neurons. Neuronal survival after axotomy is a …

The rationale for implantation of autologous human Schwann cells (SCs) in persons with
subacute spinal cord injury (SCI) is based on evidence that transplanted SCs are …

Publisher Summary This chapter focuses on the mechanisms of ligand-induced heterodimer
formation, and on signaling pathways employed by ErbB-2 and ErbB-3 in normal and …

Neuregulins (ie neuregulin-1 (NRG1), also called neu differentiation factor, heregulin, glial
growth factor, and acetylcholine receptor-inducing activity) are known to induce growth and …

ErbB receptor activation is a complex process and is dependent upon the type and number
of receptors expressed on a given cell. Previous studies with defined combinations of ErbB …

We describe the identification of Neuregulin-3 (NRG3), a novel protein that is structurally
related to the neuregulins (NRG1). The NRG1/neuregulins are a diverse family of proteins …

Aligned, electrospun polymer fibers have shown considerable promise in directing
regenerating axons in vitro and in vivo. However, in several studies, final electrospinning …