Phagocytosis is a cellular process for ingesting and eliminating particles larger than 0.5 μm
in diameter, including microorganisms, foreign substances, and apoptotic cells …

Homeostasis in healthy tissues strongly relies on cell-to-cell adhesion and cell-to-
extracellular matrix interactions. For instance, normal epithelial cells maintain tissue …

The immune system and cancer have a complex relationship with the immune system
playing a dual role in tumor development. The effector cells of the immune system can …

Integrins are the major family of adhesion molecules that mediate cell adhesion to the
extracellular matrix. They are essential for embryonic development and influence numerous …

Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

How the engagement of a T-cell receptor to antigenic peptide-loaded major
histocompatibility complex on antigen-presenting cells (APCs) initiates intracellular …

One hundred years have passed since the death of Élie Metchnikoff (1845–1916). He was
the first to observe the uptake of particles by cells and realized the importance of this …

Modulation of neutrophil recruitment and function is crucial for targeting inflammatory cells to
sites of infection to combat invading pathogens while, at the same time, limiting host tissue …

More than a decade has passed since the conceptualization of the “alarmin” hypothesis. The
alarmin family has been expanding in terms of both number and the concept. It has recently …

Inflammation is an important process of human healing response, wherein the tissues
respond to injuries induced by many agents including pathogens. It is characterized by pain …