In the mammalian brain information processing and storage rely on the complex coding and
decoding events performed by neuronal networks. These actions are based on the …

The pharmacologic profile of retigabine [RTG (international nonproprietary name);
ezogabine, EZG (US adopted name)], is different from all currently approved antiepileptic …

Psychophysical measurements indicate that human subjects can store approximately seven
short-term memories. Physiological studies suggest that short-term memories are stored by …

The M-current regulates the subthreshold electrical excitability of many neurons,
determining their firing properties and responsiveness to synaptic input. To date, however …

Members of a previously unidentified family of potassium channel subunits were cloned from
rat and human brain. The messenger RNAs encoding these subunits were widely expressed …

Action potentials in neurones are followed by a hyperpolarization, which can last up to
several seconds. This hyperpolarization has several phases that are mediated by the …

Abstract Ca2+-activated K+ (KCa) channels of small (SK) and intermediate (IK) conductance
are present in a wide range of excitable and non-excitable cells. On activation by low …

The hippocampal pyramidal cells provide an example of how multiple potassium (K)
currents co-exist and function in central mammalian neurones. The data come from CA1 and …

Although the function of sleep remains elusive, several lines of evidence suggest that sleep
has an important role in learning and memory. In light of the available data and with the …

In humans, mutations in the KCNQ2 or KCNQ3 potassium-channel genes are associated
with an inherited epilepsy syndrome. We have studied the contribution of KCNQ/M-channels …