Challenges and opportunities in NASH drug development

SA Harrison, AM Allen, J Dubourg, M Noureddin… - Nature medicine, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) and its more severe form, nonalcoholic
steatohepatitis (NASH), represent a growing worldwide epidemic and a high unmet medical …

American Association of Clinical Endocrinology clinical practice guideline for the diagnosis and management of nonalcoholic fatty liver disease in primary care and …

K Cusi, S Isaacs, D Barb, R Basu, S Caprio… - Endocrine Practice, 2022 - Elsevier
Objective To provide evidence-based recommendations regarding the diagnosis and
management of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis …

EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)

European Association for the Study of the Liver (EASL)… - Obesity Facts, 2024 - karger.com
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed non-
alcoholic fatty liver disease (NAFLD), is defined as steatotic liver disease (SLD) in the …

Impact of non-invasive biomarkers on hepatology practice: past, present and future

QM Anstee, L Castera, R Loomba - Journal of hepatology, 2022 - Elsevier
Over the last two decades, there have been tremendous advances in the non-invasive
diagnosis and risk stratification of chronic liver diseases (CLDs). Non-invasive approaches …

[HTML][HTML] Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual …

FE Mózes, JA Lee, Y Vali, O Alzoubi… - The Lancet …, 2023 - thelancet.com
Background Histologically assessed liver fibrosis stage has prognostic significance in
patients with non-alcoholic fatty liver disease (NAFLD) and is accepted as a surrogate …

Breakthroughs in therapies for NASH and remaining challenges

V Ratziu, S Francque, A Sanyal - Journal of hepatology, 2022 - Elsevier
Initially a condition that received limited recognition and whose clinical impact was
controversial, non-alcoholic steatohepatitis (NASH) has become a leading cause of chronic …

AASLD practice guidance on risk stratification and management of portal hypertension and varices in cirrhosis

DE Kaplan, C Ripoll, M Thiele, BE Fortune… - Hepatology, 2024 - journals.lww.com
This Practice Guidance from the American Association for the Study of Liver Disease
(AASLD) intends to coalesce best practice recommendations for the identification of portal …

AASLD Practice Guideline on imaging-based noninvasive liver disease assessment of hepatic fibrosis and steatosis

RK Sterling, A Duarte-Rojo, K Patel, SK Asrani… - Hepatology, 2025 - journals.lww.com
Chronic liver disease (CLD) is associated with approximately two million annual deaths
worldwide and is an enormous health burden.[1, 2] The majority of liver-related outcomes …

Non-invasive diagnosis and monitoring of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis

MA Tincopa, R Loomba - The Lancet Gastroenterology & Hepatology, 2023 - thelancet.com
Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent form of chronic liver disease
that poses challenges in diagnosis and risk stratification. Non-alcoholic steatohepatitis …

Accuracy of controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) for assessing steatosis and fibrosis in non-alcoholic fatty liver disease: A …

Y Cao, L **ang, F Qi, Y Zhang, Y Chen, X Zhou - EClinicalMedicine, 2022 - thelancet.com
Background Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease,
and among the non-invasive tests, controlled attenuation parameter (CAP) and liver stiffness …