Oxidative stress has been implicated in the pathogenesis of diverse disease states, and may
be a common pathogenic mechanism underlying many major psychiatric disorders, as the …

Dopamine (DA) is a major monoamine neurotransmitter in the brain and has essential roles
in higher functions of the brain. Malfunctions of dopaminergic signaling have been …

Mitochondria are cellular organelles involved in several biological processes, especially in
energy production. Several studies have found a relationship between mitochondrial …

Peroxynitrite (ONOO−)-mediated damage is regarded to be responsible for the cognitive
dysfunction induced by amyloid beta protein (Aβ) in Alzheimer's disease (AD). In the present …

There is accumulating evidence for oxidative stress mechanisms as common
pathophysiological pathways in diverse psychiatric disorders, which offers novel treatment …

The correlation between the affective disorders and the almost ubiquitous pathological
oxidative stress can be described in a multifactorial way, as an important mechanism of …

Studies performed in schizophrenia patients have generally suggested the presence of a
compromised antioxidant system, but this is not always consistent with specific observed …

Amyloid-β peptide (Aβ) is a central player in the pathogenesis and diagnosis of Alzheimer
disease. It aggregates to form the core of Alzheimer disease-associated plaques found in …

Background: Oxidative damage in the central nervous system is increasingly recognized as
an important pathological process in many diseases. Previously, our laboratory found that …

Schizophrenia (SCZ) is a complex mental disorder characterized by a range of symptoms,
including positive and negative symptoms, as well as cognitive impairments. Despite the …