Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …

The innate immune system is central for the maintenance of tissue homeostasis and quickly
responds to local or systemic perturbations by pathogenic or sterile insults. This rapid …

Dysregulation of mRNA translation is a frequent feature of neoplasia. Many oncogenes and
tumour suppressors affect the translation machinery, making aberrant translation a …

Plasmacytoid dendritic cells (pDCs) are important mediators of antiviral immunity through
their ability to produce large amounts of type I interferons (IFNs) on viral infection. This …

mTOR is an evolutionarily conserved serine/threonine kinase that plays a central role in
integrating environmental cues in the form of growth factors, amino acids, and energy. In the …

Long-lasting forms of synaptic plasticity and memory are dependent on new protein
synthesis. Recent advances obtained from genetic, physiological, pharmacological, and …

The potent immunosuppressive action of rapamycin is commonly ascribed to inhibition of
growth factor-induced T cell proliferation. However, it is now evident that the …

The innate inflammatory immune response must be tightly controlled to avoid damage to the
host. Here, we showed that the tuberous sclerosis complex-mammalian target of rapamycin …

Translation is a key step in the regulation of gene expression and one of the most energy-
consuming processes in the cell. In response to various stimuli, multiple signaling pathways …

Abstract Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–
Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I …