Activation of the androgen receptor (AR) and AR-driven transcriptional programs is central to
the pathophysiology of prostate cancer. Despite successful translational efforts in targeting …

The androgen-signaling axis plays a pivotal role in the pathogenesis of prostate cancer.
Since the landmark discovery by Huggins and Hodges, gonadal depletion of androgens has …

Patients with castration-resistant prostate cancer inevitably acquire resistance to
antiandrogen therapies in part because of androgen receptor (AR) mutations or splice …

Owing to the development of multiple novel therapies, there has been major progress in the
treatment of advanced prostate cancer over the last two decades; however, the disease …

Abstract The Androgen Receptor (AR), a member of the steroid hormone receptor family,
plays important roles in the physiology and pathology of diverse tissues. AR ligands, which …

The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …

The androgen receptor (AR) plays a key role in progression to incurable androgen ablation–
resistant prostate cancer (PCA). We have identified three novel AR splice variants lacking …

Purpose: Enzalutamide, a second-generation antiandrogen, was recently approved for the
treatment of castration-resistant prostate cancer (CRPC) in patients who no longer respond …

I. Introduction IN 1953 lohn Morris, an obstetrician at Yale University, reported a series of 82
individuals (80 cases collated from the literature and two cases of his own) who had a …

The androgen receptor (AR), ligand-induced transcription factor, is expressed in primary
prostate cancer and in metastases. AR regulates multiple cellular events, proliferation …