Recent advances in chemistry and therapeutic potential of functionalized quinoline motifs–a review

OO Ajani, KT Iyaye, OT Ademosun - RSC advances, 2022 - pubs.rsc.org
Quinoline, which consists of benzene fused with N-heterocyclic pyridine, has received
considerable attention as a core template in drug design because of its broad spectrum of …

A review on transition-metal mediated synthesis of quinolines

R Sharma, P Kour, A Kumar - Journal of Chemical Sciences, 2018 - Springer
Quinoline is one of the important class of heterocyclic compounds which have gained
considerable importance because of its high pharmaceutical efficacy and broad range of …

Regioselective Metal-Free Cross-Coupling of Quinoline N-Oxides with Boronic Acids

L Bering, AP Antonchick - Organic Letters, 2015 - ACS Publications
A novel and operationally simple one-step C–H bond functionalization of quinoline N-oxides
to 2-substituted quinolines was developed. This approach enables the regioselective …

An updated review on the synthesis and antibacterial activity of molecular hybrids and conjugates bearing imidazole moiety

R Rossi, M Ciofalo - Molecules, 2020 - mdpi.com
The rapid growth of serious infections caused by antibiotic resistant bacteria, especially the
nosocomial ESKAPE pathogens, has been acknowledged by Governments and scientists …

Copper-Catalyzed Cyclization for Access to 6H-Chromeno[4,3-b]quinolin-6-ones Employing DMF as the Carbon Source

Y Weng, H Zhou, C Sun, Y **e… - The Journal of Organic …, 2017 - ACS Publications
The first example of the copper-catalyzed cyclization of 4-(phenylamino)-2 H-chromen-2-
ones employing the N-methyl moiety of DMF as the source of the methine (CH) group has …

Catalyst-Free Synthesis of 2-Anilinoquinolines and 3-Hydroxyquinolines via Three-Component Reaction of Quinoline N-Oxides, Aryldiazonium Salts, and Acetonitrile

AK Dhiman, D Chandra, R Kumar… - The Journal of Organic …, 2019 - ACS Publications
A rapid microwave-assisted, catalyst-free, three-component synthesis of various 2-
anilinoquinolines from quinoline N-oxides and aryldiazonium salts in acetonitrile under …

Experimental and theoretical spectroscopic analysis, hydrogen bonding, reduced density gradient and antibacterial activity study on 2-Phenyl quinoline alkaloid

J Priscilla, DA Dhas, IH Joe, S Balachandran - Chemical Physics, 2020 - Elsevier
The main objective of the study was based on combined experimental and quantum
chemical computation methodology performed on spectroscopic analysis, structural activity …

Microwave assisted synthesis and antimicrobial potential of quinoline‐based 4‐hydrazide‐hydrazone Derivatives

OO Ajani, KT Iyaye, OY Audu… - Journal of …, 2018 - Wiley Online Library
Quinoline is a benzo‐fused pyridine which is a therapeutically important heterocycle in
medicinal chemistry research and new drug development. A series of 12 new hydrazide …

Amino acid or peptide conjugates of acridine/acridone and quinoline/quinolone-containing drugs. A critical examination of their clinical effectiveness within a twenty …

M Kukowska - European Journal of Pharmaceutical Sciences, 2017 - Elsevier
Abstract Acridines/acridones, quinolines/quinolones (chromophores) and their derivatives
constitute extremely important family of compounds in current medicine. Great significance …

Access to a new class of biologically active quinoline based 1, 2, 4-triazoles

RV Patel, SW Park - European Journal of Medicinal Chemistry, 2014 - Elsevier
As an aspect of our ongoing research in search of new antimicrobial armamentarium, a
series of 1, 2, 4-triazol-3-ylthio-acetamides was constructed and in vitro analyzed for their …