Peptide-based liquid droplets as emerging delivery vehicles
Peptides are small yet versatile building blocks of biomaterials. This Comment highlights
recent progress in the design of liquid-like microdroplets, or coacervates, based on peptides …
recent progress in the design of liquid-like microdroplets, or coacervates, based on peptides …
The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
Approaches and materials for endocytosis-independent intracellular delivery of proteins
N Chen, Y He, M Zang, Y Zhang, H Lu, Q Zhao… - Biomaterials, 2022 - Elsevier
The intracellular delivery of proteins is of great significance. For diseases such as cancer,
heart disease and neurodegenerative diseases, many important pharmacological targets …
heart disease and neurodegenerative diseases, many important pharmacological targets …
Cellular Uptake of Phase‐Separating Peptide Coacervates
Peptide coacervates self‐assembling via liquid‐liquid phase separation are appealing
intracellular delivery vehicles of macromolecular therapeutics (proteins, DNA, mRNA) owing …
intracellular delivery vehicles of macromolecular therapeutics (proteins, DNA, mRNA) owing …
Structure–Uptake Relationship Study of DABCYL Derivatives Linked to Cyclic Cell‐Penetrating Peptides for Live‐Cell Delivery of Synthetic Proteins
Modifying cyclic cell‐penetrating deca‐arginine (cR10) peptides with 4‐(4‐
dimethylaminophenylazo) benzoic acid (DABCYL) improves the uptake efficiency of …
dimethylaminophenylazo) benzoic acid (DABCYL) improves the uptake efficiency of …
Formation of versus recruitment to RNA-rich condensates: controlling effects exerted by peptide side chain identity
Liquid–liquid phase separation (LLPS), the spontaneous formation of contiguous liquid
phases with distinct compositions, has been long known in chemical systems and more …
phases with distinct compositions, has been long known in chemical systems and more …
Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells
Y Kawaguchi, S Futaki - Current Opinion in Chemical Biology, 2024 - Elsevier
The delivery of functional proteins, including antibodies, into cells opens up many
opportunities to regulate cellular events, with significant implications for studies in chemical …
opportunities to regulate cellular events, with significant implications for studies in chemical …
Fluid protein condensates for bio-inspired applications
Since the discovery of tropoelastin liquid–liquid phase separation in the 1950s, it has been
recognized that fluid protein condensates, including coacervates and liquid crystals, are …
recognized that fluid protein condensates, including coacervates and liquid crystals, are …
First direct evidence for direct cell-membrane penetrations of polycationic homopoly (amino acid) s produced by bacteria
Y Takeuchi, K Ushimaru, K Kaneda… - Communications …, 2022 - nature.com
Bacteria produce polycationic homopoly (amino acid) s, which are characterized by
isopeptide backbones. Although the biological significance of polycationic homopoly (amino …
isopeptide backbones. Although the biological significance of polycationic homopoly (amino …
Liquid-liquid phase separation in nucleation process of biomineralization
D Qin, Z He, P Li, S Zhang - Frontiers in Chemistry, 2022 - frontiersin.org
Biomineralization is a typical interdisciplinary subject attracting biologists, chemists, and
geologists to figure out its potential mechanism. A mounting number of studies have …
geologists to figure out its potential mechanism. A mounting number of studies have …