Ribosomes are universally conserved enzymes that carry out protein biosynthesis. Bacterial
and eukaryotic ribosomes, which share an evolutionarily conserved core, are thought to …

Initiation of mRNA translation is a major checkpoint for regulating level and fidelity of protein
synthesis. Being rate limiting in protein synthesis, translation initiation also represents the …

Identification of bacterial protein–protein interactions and predicting the structures of these
complexes could aid in the understanding of pathogenicity mechanisms and develo** …

Eukaryotic ribosomes are substantially larger and more complex than their bacterial
counterparts. Although their core function is conserved, bacterial and eukaryotic protein …

Crystal structures of prokaryotic ribosomes have described in detail the universally
conserved core of the translation mechanism. However, many facets of the translation …

Gene expression universally relies on protein synthesis, where ribosomes recognize and
decode the messenger RNA template by cycling through translation initiation, elongation …

Escherichia coli (E. coli) mazEF is a stress-induced toxin-antitoxin (TA) module. The toxin
MazF is an endoribonuclease that cleaves single-stranded mRNAs at ACA sequences …

Accurate protein synthesis (translation) relies on translation factors that rectify ribosome
fluctuations into a unidirectional process. Understanding this process requires structural …

Small noncoding RNAs (sRNAs) have predominantly been shown to repress bacterial
mRNAs by masking the Shine-Dalgarno (SD) or AUG start codon sequence, thereby …

To survive under conditions of stress, such as nutrient deprivation, bacterial 70S ribosomes
dimerize to form hibernating 100S particles. In γ-proteobacteria, such as Escherichia coli …